Correlation between Treatment Outcomes and Serum Vitamin D Levels As Well As Infliximab Trough Concentration among Chinese Patients with Crohn's Disease

作者全名："Song, Xiaomei; Zhang, Huihui; Wang, Hao; Li, Zhongyue; Zhou, Xiaoqin; Guo, Hong"

作者地址："[Song, Xiaomei; Wang, Hao; Guo, Hong] Chongqing Gen Hosp, Dept Gastroenterol, Chongqing, Peoples R China; [Zhang, Huihui; Li, Zhongyue; Zhou, Xiaoqin] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Childrens, Dept Gastroenterol,Chongqing Key Lab Pediat, Minist Educ Key Lab Child Dev & Disorders,Chongqin, Chongqing, Peoples R China"

通信作者："Guo, H (通讯作者)，Chongqing Gen Hosp, Dept Gastroenterol, Chongqing, Peoples R China.; Zhou, XQ (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders,Childrens, Dept Gastroenterol,Chongqing Key Lab Pediat, Minist Educ Key Lab Child Dev & Disorders,Chongqin, Chongqing, Peoples R China."

来源：GASTROENTEROLOGY RESEARCH AND PRACTICE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001083127000001

JCR分区：Q3

影响因子：2

年份：2023

卷号：2023

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background. The relationship between vitamin D (vit-D) levels and the effectiveness of infliximab (IFX) in patients with Crohn's disease (CD) remains controversial. Objective. To evaluate the interaction between vit-D levels and the response to IFX therapy in patients with CD. Methods. This was a retrospective cohort study. Serum vit-D and IFX trough concentrations (TC) were measured in 84 patients, and statistical analyses were performed. Results. The total vit-D deficiency rate at enrollment, at week 14 and week 38, was 64.3%, 41.67%, and 37.5%, respectively (P<0.001). CD activity index (CDAI) (120, range, 93-142.75) and simplified endoscopic activity score for CD (SES-CD) (2, range, 0-4) at week 14 were lower than that of enrollment (CDAI, 136.5, range, 101.25-196; SES-CD 13, range, 5-23) (P<0.001). The biochemical remission (BR), clinical remission (CR), endoscopic remission (ER), and response (ERe) rates of week 38 were 76.1%, 88.5%, 22.4%, and 67.2%, respectively. vit-D levels at enrollment were positively correlated with CDAI at week 38 (P=0.024). IFX serum TC was related to BR (P=0.036), CR (P=0.032) at week 14, and ERe (P=0.009) at week 38. Conclusion. Among Chinese patients with CD, vit-D levels prior to IFX therapy are related to CDAI scores, and IFX serum TC is associated with BR, CR, and ERe."

基金机构："The reported work was supported by the Special Project of Chongqing Technology Commission (cstc2019jscx-msxmX0257), Chongqing Municipal Education Commission (grant number (2021) 27-KJQN202100455), National Clinical Research Center, and Children's Hospital [cstc2019jscx-msxmX0257]; Special Project of Chongqing Technology Commission [(2021) 27-KJQN202100455]; Chongqing Municipal Education Commission; National Clinical Research Center [(2021) 60-NCRCCHD-2021-YP-18]; Children's Hospital of Chongqing Medical University"

基金资助正文："The reported work was supported by the Special Project of Chongqing Technology Commission (cstc2019jscx-msxmX0257), Chongqing Municipal Education Commission (grant number (2021) 27-KJQN202100455), National Clinical Research Center, and Children's Hospital of Chongqing Medical University (grant number (2021) 60-NCRCCHD-2021-YP-18)."