Magnetic Field-Directed Deep Thermal Therapy via Double-Layered Microneedle Patch for Promoting Tissue Regeneration in Infected Diabetic Skin Wounds

作者全名："He, Dengfeng; Liu, Xingmou; Jia, Jiezhi; Peng, Bo; Xu, Na; Zhang, Qing; Wang, Shang; Li, Lei; Liu, Menglong; Huang, Yong; Zhang, Xiaorong; Yu, Yunlong; Luo, Gaoxing"

作者地址："[He, Dengfeng; Liu, Xingmou; Jia, Jiezhi; Xu, Na; Zhang, Qing; Liu, Menglong; Huang, Yong; Zhang, Xiaorong; Yu, Yunlong; Luo, Gaoxing] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Inst Burn Res, Chongqing 400038, Peoples R China; [Peng, Bo] Sichuan Univ, West China Hosp, Chengdu 610064, Peoples R China; [Wang, Shang] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China; [Li, Lei] Chongqing Univ Posts & Telecommun, Chongqing Key Lab Complex Syst & Bion Control, Chongqing 400065, Peoples R China"

通信作者："Liu, XM; Yu, YL; Luo, GX (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, Inst Burn Res, Chongqing 400038, Peoples R China."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001088245700001

JCR分区：Q1

影响因子：18.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：anti-inflammatory treatment; bilayer-structured microneedles; chronic diabetic wound healing; magneto-thermal therapy; minimally invasive treatment

摘要："Although near-infrared (NIR) light-based photothermal therapies have shown therapeutic potential for infected wounds, the attenuation of NIR light intensity in tissue has severely limited the usage in deep bacterial infections. Herein, magneto-thermal responsive bilayer microneedles (Fe-Se-HA MNs) consisting of functionalized hyaluronic acid (HA), ferro-ferric oxide (Fe3O4), and micelle-protected selenium nanoparticles (SeNPs@LAS) are constructed to overcome this challenge based on a self-designed disk-shaped electromagnetic field device (Disk-ZVS). The electromagnetic field generated by the Disk-ZVS shows virtually no intensity attenuation in living tissue. Finite element simulations showed that the field intensity and electromagnetic loss are concentrated on the tips of Fe-Se-HA MNs. The MNs are able to puncture hard scabs, penetrate into bacterial biofilms, and perform effective magnetic-thermal conversion for deep hyperthermia sterilization. Following, the Fe-Se-HA MNs can be gradually degraded by excessive hyaluronidase in diabetic wound to release SeNPs, which reduce reactive oxygen species (ROS) to regulate wound redox homeostasis. Meanwhile, the SeNPs are beneficial to angiogenesis, which facilitates blood vessel formation and promotes wound repair. Therefore, various functions can be achieved for the Fe-Se-HA MNs, such as magneto-thermal disinfection, deep and non-invasive tissue penetration, anti-inflammation, and pro-angiogenesis, which shows great potential as an adjunctive therapy for infected diabetic wounds."

基金机构："The authors are grateful for financial support from the National Key Ramp;D Program of China (No. 2021YFA1101100), the National Natural Science Foundation of China (No. 82202486 and 81920108022), the China Postdoctoral Science Foundation (No. 2022M713833) [2021YFA1101100]; National Key Ramp;D Program of China [82202486, 81920108022]; National Natural Science Foundation of China [2022M713833]; China Postdoctoral Science Foundation [2021XM3019]; Special Support of Chongqing Postdoctoral Research Project"

基金资助正文："The authors are grateful for financial support from the National Key R & D Program of China (No. 2021YFA1101100), the National Natural Science Foundation of China (No. 82202486 and 81920108022), the China Postdoctoral Science Foundation (No. 2022M713833), and the Special Support of Chongqing Postdoctoral Research Project (No. 2021XM3019). The authors would like to thank Qiong Wang from Shiyanjia Lab () for the TEM analysis."