Brain network structural connectome abnormalities among youth with attention-deficit/hyperactivity disorder at varying risk for bipolar I disorder: a cross-sectional graph-based magnetic resonance imaging study

作者全名："Zhu, Ziyu; Lei, Du; Qin, Kun; Li, Xiuli; Li, Wenbin; Tallman, Maxwell J.; Patino, L. Rodrigo; Fleck, David E.; Aghera, Veronica; Gong, Qiyong; Sweeney, John A.; Mcnamara, Robert K.; Delbello, Melissa P."

作者地址："[Zhu, Ziyu; Qin, Kun; Li, Xiuli; Gong, Qiyong] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Ctr Med Imaging,Dept Radiol, Chengdu, Peoples R China; [Zhu, Ziyu; Qin, Kun; Tallman, Maxwell J.; Patino, L. Rodrigo; Fleck, David E.; Aghera, Veronica; Sweeney, John A.; Mcnamara, Robert K.; Delbello, Melissa P.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China; [Li, Xiuli] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China; [Li, Wenbin] Zhengzhou Univ, Affiliated Hosp 1, Dept Magnet Resonance Imaging, Zhengzhou, Peoples R China; [Gong, Qiyong] Sichuan Univ, West China Hosp, Funct & Mol Imaging Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China; [Gong, Qiyong] Sichuan Univ, West China Xiamen Hosp, Dept Radiol, Xiamen, Fujian, Peoples R China; [Lei, Du] Chongqing Med Univ, Coll Med Informat, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Gong, QY (通讯作者)，Sichuan Univ, West China Xiamen Hosp, Dept Radiol, Xiamen, Fujian, Peoples R China.; Lei, D (通讯作者)，Chongqing Med Univ, Coll Med Informat, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF PSYCHIATRY & NEUROSCIENCE

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001090191000001

JCR分区：Q1

影响因子：4.1

年份：2023

卷号：48

期号：4

开始页：E315

结束页：E324

文献类型：Article

关键词：　

摘要："Background:Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent among youth with or at familial risk for bipolar-I disorder (BD-I), and ADHD symptoms commonly precede and may increase the risk for BD-I; however, associated neuropathophysiological mechanisms are not known. In this cross-sectional study, we sought to investigate brain structural network topology among youth with ADHD, with and without familial risk of BD-I.Methods:We recruited 3 groups of psychostimulant-free youth (aged 10-18 yr), namely youth with ADHD and at least 1 biological parent or sibling with BD-I (high-risk group), youth with ADHD who did not have a first- or second-degree relative with a mood or psychotic disorder (low-risk group) and healthy controls. We used graph-based network analysis of structural magnetic resonance imaging data to investigate topological properties of brain networks. We also evaluated relationships between topological metrics and mood and ADHD symptom ratings.Results:A total of 149 youth were included in the analysis (49 healthy controls, 50 low-risk youth, 50 high-risk youth). Low-risk and high-risk ADHD groups exhibited similar differences from healthy controls, mainly in the default mode network and central executive network. We found topological alterations in the salience network of the high-risk group, relative to both low-risk and control groups. We found significant abnormalities in global network properties in the high-risk group only, compared with healthy controls. Among both low-risk and high-risk ADHD groups, nodal metrics in the right triangular inferior frontal gyrus correlated positively with ADHD total and hyperactivity/impulsivity subscale scores.Limitations:The cross-sectional design of this study could not determine the relevance of these findings to BD-I risk progression.Conclusion:Youth with ADHD, with and without familial risk for BD-I, exhibit common regional abnormalities in the brain connectome compared with healthy youth, whereas alterations in the salience network distinguish these groups and may represent a prodromal feature relevant to BD-I risk."

基金机构："National Institute of Mental Health [R01 MH097818]; National Natural Science Foundation of China [81820108018, 82027808]; Chongqing Talents Exceptional Young Talents Project"

基金资助正文："This study was supported by the National Institute of Mental Health (no. R01 MH097818 to Melissa DelBello and Robert McNamara) and the National Natural Science Foundation of China (no. 81820108018 and 82027808 to Qiyong Gong). Du Lei was supported by the Chongqing Talents Exceptional Young Talents Project. Funding sources had no role in the design and conduct of this study; collection, management, analysis or interpretation of the data; preparation, review or approval of the manuscript; or decision to submit the manuscript for publication."