Circulating sNinj1 as a novel predictor of prognosis and severity in hepatocellular carcinoma

作者全名："Yan, Ling; Su, Wei; Gan, Delu; Li, Dandan; Mai, Li; Wang, Bo; Wang, Li; Peng, Lanlang; Jiang, Linshan; Wang, Zhengao; Hu, Qin; Chen, Weixian"

作者地址："[Yan, Ling; Su, Wei; Gan, Delu; Li, Dandan; Mai, Li; Wang, Bo; Wang, Li; Peng, Lanlang; Jiang, Linshan; Hu, Qin; Chen, Weixian] Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing, Peoples R China; [Wang, Zhengao] South China Univ Technol, Sch Mat Sci & Engn, Guangzhou, Peoples R China; [Hu, Qin; Chen, Weixian] Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing 400010, Peoples R China"

通信作者："Hu, Q; Chen, WX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Lab Med, Chongqing 400010, Peoples R China."

来源：CLINICA CHIMICA ACTA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001090998100001

JCR分区：Q2

影响因子：3.2

年份：2023

卷号：550

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：sNinj1; Hepatocellular carcinoma; Prognosis; Severity

摘要："Background: The occurrence and development of HCC are closely associated with cell death. Recently, researchers found that Ninj1 plays a pivotal role in PMR during different types of cell death. However, the importance of Ninj1 in HCC has not been extensively investigated. Methods: This study included 102 newly diagnosed HCC patients and 102 sex and age-matched NCs. Circulating sNinj1 was assessed by ELISA. Serum LDH and IL-1ss were detected through a chemiluminescence assay. The correlations of these biomarkers with disease severity and their potential as prognostic predictors for HCC were evaluated. The dynamic changes of sNinj1, LDH, and IL-1ss levels before and after treatment were recorded. Results: Serum levels of sNinj1, IL-1ss, and LDH were significantly higher in HCC patients. Our study found that the sNinj1 level was positively correlated with tumor size, metastasis, and staging. ROC analysis indicated that the AUC of sNinj1 in differentiating HCC from NCs was 0.85. As a result of tumor thrombosis and invasion of the hepatic vein, sNinj1 ' s AUCs were 0.71 and 0.73, respectively. After partial resection and TACE treatment, serum sNinj1 and LDH exhibited similar change trends. A one-year follow-up analysis also demonstrated that HCC patients with high sNinj1 had significantly poorer survival than those with low sNinj1. Conclusions: The serum sNinj1 is another diagnostic biomarker supporting the HCC diagnosis. More importantly, it has been shown that circulating sNinj1 reveals potential as a novel predictor of HCC severity and prognosis."

基金机构：National Natural Science Foundation of China [81873971]

基金资助正文：This work was supported by the National Natural Science Foundation of China [81873971] .