A Bivariate Twin Study of Cortical Surface Area and Verbal and Nonverbal Intellectual Skills in Adolescence

作者全名："Yang, Shu; Ma, Xingshun; Xia, Xiaodi; Qiao, Zimei; Huang, Miao; Wang, Na; Hu, Xiaomei; Zhang, Xiaowei; Deng, Wei; Kang, Line; Li, Xiao; Hao, Guangjun; Xi, Junfeng; Meng, Huaqing; Li, Tao; Hou, Xiao; Fu, Yixiao"

作者地址："[Yang, Shu; Xia, Xiaodi; Li, Xiao; Meng, Huaqing; Fu, Yixiao] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 YouYi Rd, Chongqing 400016, Peoples R China; [Ma, Xingshun; Qiao, Zimei; Huang, Miao; Wang, Na; Kang, Line; Hao, Guangjun; Xi, Junfeng] First Hosp Yulin, Dept Neurol, Yulin 719000, Shanxi, Peoples R China; [Hu, Xiaomei] Zunyi Med Coll, Affiliated Hosp, Dept Abdominal Oncol, Zunyi 563003, Guizhou, Peoples R China; [Zhang, Xiaowei] BeiGene Shanghai Co Ltd, Shanghai, Peoples R China; [Deng, Wei; Li, Tao] Zhejiang Univ, Hangzhou Peoples Hosp 7, Affiliated Mental Hlth Ctr, Sch Med, 305 Tianmushan Rd, Hangzhou 310063, Zhejiang, Peoples R China; [Hou, Xiao] Chongqing Med & Pharmaceut Coll, Chongqing 400016, Peoples R China"

通信作者："Fu, YX (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, 1 YouYi Rd, Chongqing 400016, Peoples R China.; Li, T (通讯作者)，Zhejiang Univ, Hangzhou Peoples Hosp 7, Affiliated Mental Hlth Ctr, Sch Med, 305 Tianmushan Rd, Hangzhou 310063, Zhejiang, Peoples R China.; Hou, X (通讯作者)，Chongqing Med & Pharmaceut Coll, Chongqing 400016, Peoples R China."

来源：NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001091807100001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：530

期号：　

开始页：173

结束页：180

文献类型：Article

关键词：twin study; adolescents; cortical surface area; intelligence; heritability

摘要："Understanding the biological basis of cognitive differences between individuals is the goal in human intelligence research. The surface area of the cortex is considered to be a key determinant of human intelligence. Adolescence is a period of development characterized by physiological, emotional, behavioral, and psychosocial changes, which is related to the recombination and optimization of the cerebral cortex, and cognitive ability changes significantly in children and adolescents. This study examined the effects of common genetic and envi-ronmental factors between the surface area of the cerebral cortex and intelligence in typical developing adoles-cents (twins, n = 114, age 12-18 years old). Cortical surface area data were parsed into subregions (i.e., frontal, parietal, occipital, and temporal areas) and intelligence into verbal and nonverbal skills. We found a phenotypic correlation between regional surface areas and verbal intelligence. No correlation was observed between regional surface areas and nonverbal intelligence, except for the occipital lobe and the right hemisphere. In the bivariate twin analyses, the differences in phenotypic correlation between regional surface areas and verbal intelligence were not due to unshared environmental effects or measurement error, but to genetic effects. In summary, the cur-rent study has broadened the previous genetic investigations of cognitive ability and cortical surface area.(c) 2023 IBRO. Published by Elsevier Ltd. All rights reserved."

基金机构："Senior Medical Talents Program of Chongqing for Yong and Middle-aged; Program for Youth Innovation in Future Medicine, Chongqing Medical University [w0107]; Natural Science Foundation Project of Chongqing [CSTB2022NSCQ-MSX0121]"

基金资助正文："This work was supported by the following organizations and projects: Senior Medical Talents Program of Chongqing for Yong and Middle-aged; Program for Youth Innovation in Future Medicine, Chongqing Medical University (w0107) ; Natural Science Foundation Project of Chongqing (CSTB2022NSCQ-MSX0121) ."