Imaging Progression Under Low Respiratory Viral Load of SARS-CoV-2 Omicron Variant Infection: A Retrospective Study in China

作者全名："Li, Qi; Wang, Yongli; Liu, Huawen; Peng, Hailang; Xiang, Jianglin; Guo, Shuliang"

作者地址："[Li, Qi] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Wang, Yongli; Xiang, Jianglin] Chongqing Univ Three Gorges Hosp, Dept Infect Dis, Chongqing 404000, Peoples R China; [Liu, Huawen] Chongqing Univ Three Gorges Hosp, Dept Oncol, Chongqing 404000, Peoples R China; [Peng, Hailang; Guo, Shuliang] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China"

通信作者："Wang, YL; Xiang, JL (通讯作者)，Chongqing Univ Three Gorges Hosp, Dept Infect Dis, Chongqing 404000, Peoples R China.; Guo, SL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001094905100001

JCR分区：Q2

影响因子：2.9

年份：2023

卷号：16

期号：　

开始页：6795

结束页：6806

文献类型：Article

关键词：severe acute respiratory syndrome coronavirus-2; Omicron; pneumonia; computed tomography; viral load

摘要："Purpose: To investigate the computed tomography (CT) findings of SARs-CoV-2 Omicron variant in relation to respiratory viral loads determined by cycle threshold values in reverse-transcription polymerase chain reaction (RT-PCR).Materials and Methods: From October 2022 to November 2022, 74 hospitalized patients with Omicron were included in this retrospective study. The radiological features, CT involvement scores in relation to the respiratory viral load, and factors associated with imaging progression (IP) after the RT-PCR results turned negative were analyzed.Results: The most common CT patterns of Omicron were multiple round-like or patchy ground-glass opacity (GGO) or mixed GGO in the peripheral or diffuse areas. The grading of CT involvement scores exhibited an inverse pattern compared to viral loads from day 1 to day 8 and from day 13 to day 20 after diagnosis. Among the 65 patients with complete imaging data, 45 (69.23%) showed IP with clinical warning indicators of disease exacerbation negative in 34 and positive in 11. Patients with IP were older than those with non-IP (NIP); the erythrocyte sedimentation rates, procalcitonin levels, and D-dimer levels on admission of patients with IP were significantly higher than those of patients with NIP, whereas the immunoglobulin (Ig) G antibody level on admission and CT involvement score on initial CT of patients with IP were significantly lower than those of patients with NIP (all P < 0.05).Conclusion: For patients with Omicron, the IP of lung abnormalities is common when the viral load decreases. Under these circumstances, paying attention to clinical warming indicators of disease progression may contribute to better patient management and the mitigation of severe pneumonia."

基金机构：Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022MSXM147]; Chongqing Health Commission (Chongqing Talent Program-Innovation leading Talent Research Project) of China [CQYC20210303348]

基金资助正文：This study was supported by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2022MSXM147) and Chongqing Health Commission (Chongqing Talent Program-Innovation leading Talent Research Project) (CQYC20210303348) of China.