Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy

作者全名："Liang, Fuming; You, Qing; Ma, Xiaopeng; Wang, Huayi; Wang, Chen; He, Zhaohui; Yang, Yanlian; Zhu, Ling"

作者地址："[Liang, Fuming; You, Qing; Wang, Huayi; Wang, Chen; Yang, Yanlian; Zhu, Ling] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China; [Liang, Fuming; He, Zhaohui] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China; [You, Qing; Wang, Huayi; Wang, Chen; Yang, Yanlian; Zhu, Ling] Univ Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China; [Ma, Xiaopeng] Univ Sci & Technol China, Anhui Prov Hosp, Affiliated Hosp 1, Hefei 230000, Peoples R China"

通信作者："Yang, YL; Zhu, L (通讯作者)，Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China.; He, ZH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China.; Yang, YL; Zhu, L (通讯作者)，Univ Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China."

来源：NANO RESEARCH

ESI学科分类：PHYSICS

WOS号：WOS:001095328300001

JCR分区：Q1

影响因子：9.5

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：brain disease; nano-imaging agent; blood-brain barrier; environmentally responsive imaging; treatment

摘要："Precise imaging is essential for the accurate diagnosis and surgical guidance of brain diseases but it is challenging due to the difficulties in crossing the blood-brain barrier (BBB), the difficulties in disease lesion targeting, and the limited contrast in the brain environment. Nano-imaging agents were characterized by functionalized modifications, high contrast, small size, and high biocompatibility, thus providing advantages in BBB crossing, brain targeting, imaging resolution, and real-time monitoring, holding great potential in brain disease imaging. Specific characteristics in brain environment and brain diseases (e.g., marker proteins on the BBB, the pathogenic proteins in the neurodegenerative diseases or brain tumors, and the tumor and inflammatory microenvironment) provide opportunities for the functionalized nano-imaging agents to improve BBB crossing and disease targeting. Moreover, the versatile nano-imaging agents are endowed with therapeutic agents to facilitate the theranostics of brain diseases. Here, we summarized the common materials and imaging techniques of nano-imaging agents and their imaging treatment applications. We discussed their BBB penetration, environmental response for disease targeting, and therapeutic effects. We also provided insights on the advantages, challenges, and application of nano-imaging agents in detecting and treating brain diseases such as neurodegenerative diseases, brain tumors, stroke, and traumatic brain injury. These discussions will help develop nano-imaging agents-based theranostic platforms for the precise diagnosis and treatment of brain diseases."

基金机构："The authors are grateful to the National Key Research and Development Program of China (No. 2021YFA1201504), the Strategic Priority Research Program of the Chinese Academy of Science (No. XDB36000000), and the National Natural Science Foundation of China ( [2021YFA1201504]; National Key Research and Development Program of China [XDB36000000]; Strategic Priority Research Program of the Chinese Academy of Science [31971295, 21721002, 81870927]; National Natural Science Foundation of China"

基金资助正文："The authors are grateful to the National Key Research and Development Program of China (No. 2021YFA1201504), the Strategic Priority Research Program of the Chinese Academy of Science (No. XDB36000000), and the National Natural Science Foundation of China (Nos. 31971295, 21721002, and 81870927)."