Ultraearly Intraventricular Hemorrhage Growth Predicts Early Neurologic Deterioration and Poor Functional Outcome After Acute Intracerebral Hemorrhage

作者全名："Lv, Xin-Ni; Cheng, Jing; Liu, Xue-Yun; Liu, Jin-Cheng; Deng, Lan; Li, Zuo-Qiao; Pu, Ming-Jun; Chen, Chu; Li, Qi"

作者地址："[Li, Qi] Hosp Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Lv, Xin-Ni; Deng, Lan; Li, Zuo-Qiao; Pu, Ming-Jun; Chen, Chu; Li, Qi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Cheng, Jing] Chongqing Med Univ, Dept Neurol & Neurosurg, Affiliated Hosp 3, Chongqing, Peoples R China; [Liu, Xue-Yun] Anhui Med Univ, Affiliated Hosp 2, Dept Neurol, Hefei, Peoples R China; [Liu, Jin-Cheng] Xiangyang Hosp Tradit Chinese Med, Dept Neurol, Xiangyang, Hubei, Peoples R China"

通信作者："Li, Q (通讯作者)，Hosp Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF THE AMERICAN HEART ASSOCIATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001100930700044

JCR分区：Q1

影响因子：5

年份：2023

卷号：12

期号：21

开始页：　

结束页：　

文献类型：Article

关键词：early neurologic deterioration; intracerebral hemorrhage; intraventricular hemorrhage growth; outcome

摘要："BackgroundThe presence of intraventricular hemorrhage (IVH) was extensively investigated and was associated with poor outcome in patients with intracerebral hemorrhage (ICH). However, the effect of the speed of ventricular bleeding on outcomes is unknown.Methods and ResultsWe prospectively included patients with ICH who had baseline computed tomography scans within 6 hours after ictus between January 2016 and October 2021. The clinical characteristics were compared between patients with and without early neurologic deterioration (END). Ultraearly IVH growth (uIVHG) was defined as baseline IVH volume by onset-to-imaging time. The association between uIVHG and outcomes was assessed by using multivariable logistic regression analysis. We established the ultraearly IVH growth (uIVH) score and compared the areas under the receiver operating characteristic curves of the existing scores for predicting END. A total of 299 patients were finally enrolled. Of those, 38 patients (12.7%) experienced END at 24 hours and 89 patients (29.8%) had poor outcomes at 90 days. After adjustment for confounding factors, uIVHG (odds ratio, 1.061 [95% CI, 1.011-1.113]; P=0.016) was independently associated with END in multivariable analysis. A prediction score was developed on the basis of the logistic model. The uIVH score was developed as a sum of individual points (0-6) based on age, hematoma volume, National Institutes of Health Stroke Scale, hematoma expansion, and uIVHG >= 2.5 mL/h. In comparison with the ICH score and modified Emergency Department ICH Scale, the uIVH score exhibited best performance in the prediction of END.ConclusionsuIVHG is associated with early neurologic deterioration and poor functional outcome in patients with ICH."

基金机构：We thank all the individuals who participated in the study. All written permission was obtained from patients (or their legal representatives). Drs Lv and Q. Li were responsible for the study concept and design and had full access to all of the data in the

基金资助正文："We thank all the individuals who participated in the study. All written permission was obtained from patients (or their legal representatives). Drs Lv and Q. Li were responsible for the study concept and design and had full access to all of the data in the study. Drs Lv, Cheng, X.-Y. Liu, J.-C. Liu, Deng, Z.-Q. Li, Pu, Chen, and Q. Li did the acquisition, analysis, or interpretation of data. Dr Lv drafted the manuscript. Drs Lv, Cheng, and Q. Li did the critical revision of the manuscript. Drs Lv, Cheng, and Q. Li did the statistical analysis. Drs Lv and Q. Li obtained funding. Dr Q. Li was responsible for administrative, technical, or material support."