A comparative study on laparoscopic and open surgical approaches for perforated peptic ulcer repair: efficacy and outcomes analysis

作者全名："Li, Zi-Wei; Tong, Yue; Liu, Fei; Liu, Xu-Rui; Lv, Quan; Tang, Kai-Lin; Li, Lian-Shuo; Liu, Xiao-Yu; Zhang, Wei; Peng, Dong"

作者地址："[Li, Zi-Wei; Tong, Yue; Liu, Fei; Liu, Xu-Rui; Lv, Quan; Tang, Kai-Lin; Li, Lian-Shuo; Liu, Xiao-Yu; Zhang, Wei; Peng, Dong] Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing 400016, Peoples R China"

通信作者："Peng, D (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Chongqing 400016, Peoples R China."

来源：LANGENBECKS ARCHIVES OF SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001101210000001

JCR分区：Q2

影响因子：2.1

年份：2023

卷号：408

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Peptic ulcer perforation; Repair surgery; Mortality; Complication

摘要："PurposeThis study aimed to compare the clinical outcomes of the clinical outcomes of laparoscopic and open sutures for peptic ulcer perforation (PPU).Materials and methodsPubMed, EMBASE, and Cochrane Library databases were searched for eligible studies from inception to March 31, 2023. Odds ratios (OR) and 95% confidence intervals (Cl) were also calculated. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included studies. This study was performed using the Stata (V.16.0) software.ResultsA total of 29 studies involving 17,228 patients were included in this study. In terms of postoperative outcomes, the laparoscopic group had a shorter postoperative hospital stay (MD = -0.29, 95%CI = -0.44 to -0.13, P = 0.00), less blood loss (MD = -0.45, 95%CI = -0.82 to -0.08, P = 0.02), fewer wound infection (OR = 0.20, 95%CI = 0.17 to 0.24, P = 0.00), fewer pneumonia (OR = 0.59, 95%CI = 0.41 to 0.87, P = 0.01), fewer respiratory complications (OR = 0.26, 95%CI = 0.13 to 0.55, P = 0.00) and lower postoperative morbidity (OR = 0.51, 95%CI = 0.33 to 0.78, P = 0.00). The laparoscopic group had a lower mortality rate (OR = 0.36, 95%CI = 0.27 to 0.49, P = 0.00) than the open group. We also found that the laparoscopic group had a higher overall complication rate than the open group (OR = 0.45, 95%CI = 0.34 to 0.60, P = 0.00).ConclusionLaparoscopic repair was associated with a lower risk of mortality than open repair in patients with PPU. Laparoscopic repair may be a better option in patients with PPU."

基金机构：We acknowledge all authors whose publications are referred to in our article.

基金资助正文：We acknowledge all authors whose publications are referred to in our article.