Association between inflammatory cytokines and oxidative stress levels in aqueous humor with axial length in human myopia

作者全名："Yu, Qi; Wang, Chuqiao; Liu, Zhihao; Yue, Yu; Hsiao, Yuwen; Zhou, Qimin; Zhou, Jibo"

作者地址："[Yu, Qi; Wang, Chuqiao; Liu, Zhihao; Yue, Yu; Hsiao, Yuwen; Zhou, Jibo] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Hlth Sci & Technol, Dept Ophthalmol,Sch Med, Shanghai, Peoples R China; [Yu, Qi; Wang, Chuqiao; Liu, Zhihao; Yue, Yu; Hsiao, Yuwen; Zhou, Jibo] Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai 200011, Peoples R China; [Yu, Qi] Shanghai Jiao Tong Univ, Xin Hua Hosp, Dept Ophthalmol, Sch Med, Shanghai 200092, Peoples R China; [Wang, Chuqiao; Liu, Zhihao] Shanghai Tongji Univ, Peoples Hosp 10, Dept Ophthalmol, Sch Med, Shanghai 200072, Peoples R China; [Yue, Yu] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol,Chongqing Branch,Natl, Chongqing, Peoples R China; [Hsiao, Yuwen] Shanghai Aier Eye Hosp, Dept Ophthalmol, Shanghai 200336, Peoples R China; [Zhou, Qimin] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai 200011, Peoples R China"

通信作者："Zhou, JB (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Hlth Sci & Technol, Dept Ophthalmol,Sch Med, Shanghai, Peoples R China.; Zhou, QM (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai 200011, Peoples R China."

来源：EXPERIMENTAL EYE RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001101238200001

JCR分区：Q1

影响因子：3

年份：2023

卷号：237

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Aqueous humor; Correlation study; Inflammatory cytokine; Myopia; Oxidative stress

摘要："This study investigated the content of inflammatory cytokines and oxidative stress levels in the aqueous humor (AH) of patients with high myopia (HM) and explored the relationship between these factors and the axial length (AL) of the eye, to explore the roles of mild intraocular inflammation and oxidative stress imbalance in the occurrence and development of myopia. AH samples from 40 patients (70 eyes) were collected during implantable collamer lens (ICL-V4c) surgery. The subjects were divided into three groups according to AL: group A (AL <= 26 mm), group B (26 < AL <= 28 mm), and group C (AL >= 28 mm). The concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), and interleukin-1 beta (IL-1 beta) in the AH of the three groups were measured using the Luminex system. Oxidative stress levels were measured using reagent kits targeting total antioxidant capacity (T-AOC), catalase (CAT), and nitric oxide (NO) and malonaldehyde (MDA) content. The results showed compared with group A, IL-1 beta, MMP-2, and IL-6 concentrations were significantly higher and T-AOC levels were significantly lower in group C. There were no significant differences in CAT, NO, MDA, or TNF-alpha levels among the groups. The concentrations of IL-6 (r = 0.379, p = 0.016), MMP-2 (r = 0.469, p = 0.002), and MDA (r = 0.354, p = 0.025) in AH were positively correlated with the AL, whereas T-AOC (r = -0.678, p = 0.000) was negatively correlated with AL. These results suggest that mild intraocular inflammation and oxidative stress imbalance may be associated with myopia. Further experiments are needed to confirm the role of mild intraocular inflammation and oxidative stress imbalance in the occurrence and development of myopia."

基金机构："Clinical Research Program of the Nineth People's Hospital, Shanghai Jiao Tong University School of Medicine [JYLJ202117]; Shanghai Municipal Health Commission [202140416]; Shanghai Municipal Commission of Health and Family Planning [2018ZHYL0221]; National Natural Science Foundation of China [81770934]; Shanghai Key Clinical Specialty; Shanghai Eye Disease Research Center [2022ZZ01003]"

基金资助正文："This research was supported by grants from the Clinical Research Program of the Nineth People's Hospital, Shanghai Jiao Tong University School of Medicine (JYLJ202117) , Shanghai Municipal Health Commission (202140416) , Shanghai Municipal Commission of Health and Family Planning (2018ZHYL0221) , National Natural Science Foundation of China (81770934) , Shanghai Key Clinical Specialty, and Shanghai Eye Disease Research Center (2022ZZ01003) ."