Risk factors and timing of complication presentation following primary hypospadias repair in adolescents

作者全名："Ye, Zi-Han; Wang, Chong; Zhang, Zhi-Cheng; Chen, Hong-Song; Wang, Xiao; Liu, Xing; Wei, Guang-Hui"

作者地址："[Ye, Zi-Han; Wang, Chong; Zhang, Zhi-Cheng; Chen, Hong-Song; Wang, Xiao; Liu, Xing; Wei, Guang-Hui] Chongqing Med Univ, Childrens Hosp, Dept Urol, Chongqing, Peoples R China; [Ye, Zi-Han; Wang, Chong; Zhang, Zhi-Cheng; Chen, Hong-Song; Wang, Xiao; Liu, Xing; Wei, Guang-Hui] Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ, China Int Sci & Technol Cooperat Base Child Dev &, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Ye, Zi-Han; Wang, Chong; Zhang, Zhi-Cheng; Chen, Hong-Song; Wang, Xiao; Liu, Xing; Wei, Guang-Hui] Chongqing Key Lab Children Urogenital Dev & Tissue, Chongqing, Peoples R China; [Liu, Xing] Chongqing Med Univ, Childrens Hosp, Dept Urol, 136 Zhongshan Rd, Chongqing 400014, Peoples R China"

通信作者："Liu, X (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Urol, 136 Zhongshan Rd, Chongqing 400014, Peoples R China."

来源：INTERNATIONAL JOURNAL OF UROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001107531100001

JCR分区：Q3

影响因子：1.8

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：adolescents; follow-up studies; hypospadias; postoperative complications; risk factors

摘要："Objectives: To evaluate the risk factors for postoperative complications in adolescents who undergo primary hypospadias repair and determine the time required for complication detection.Methods: Our study included patients classified as Tanner stages three to five who underwent primary hypospadias repairs at our hospital from January 2015 to August 2022. The patients' baseline information, clinical characteristics, postoperative complications, and time to complication detection were collected. Cox regression analysis, ROC curves, Kaplan-Meier survival analyses, and the Mann-Whitney U test were used.Results: The study comprised 143 patients, with a median age of 12.58 years. Postoperative complications were experienced by 66 patients. The length of the urethral defect was identified as an independent risk factor for postoperative complications. The ROC curve analysis identified 3 cm as the optimal cutoff value for the length of the urethral defect. The median time to complication detection was 30.5 days (IQR 23 to 209.25). 89.4% of the complications were identified within the first year. Patients with a urethral defect of <3 cm experienced a significantly longer time for the detection of urethral fistula compared to those with a urethral defect of >= 3 cm (p = 0.047).Conclusions: Our data indicate that adolescents with a urethral defect >= 3 cm have a higher risk of postoperative complications. Although most complications were identified within the first year, conducting long-term follow-ups for adolescents is recommended to identify potential subsequent complications that may arise from persistent urethral alterations."

基金机构："This work was supported by a grant from the National Natural Science Foundation of China (No. 81970571). Zihan Ye has received research support from Program for Youth Innovation in Future Medicine, Chongqing Medical University, Yuzhong, Chongqing, Peoplea [81970571]; National Natural Science Foundation of China; Program for Youth Innovation in Future Medicine, Chongqing Medical University, Yuzhong, Chongqing, Peopleapos;s Republic of China"

基金资助正文："This work was supported by a grant from the National Natural Science Foundation of China (No. 81970571). Zihan Ye has received research support from Program for Youth Innovation in Future Medicine, Chongqing Medical University, Yuzhong, Chongqing, People & apos;s Republic of China. The funders did not contribute to the study & apos;s design, data collection, analysis, interpretation, or manuscript writing. We express our profound gratitude to all the patients and parents who participated in this study, as well as to the doctors and nurses who provided care for the patients at our hospital."