Reversed Septal Curvature Is Associated With Nonsustained Ventricular Tachycardia in Hypertrophic

作者全名："He, Ya; Zhou, Jianzhong"

作者地址："[He, Ya; Zhou, Jianzhong] Chongqing Med Univ, Affiliated Hosp 1, Div Cardiol, Chongqing, Peoples R China"

通信作者："Zhou, JZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Div Cardiol, Chongqing, Peoples R China."

来源：AMERICAN JOURNAL OF CARDIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001113898800001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：210

期号：　

开始页：195

结束页：200

文献类型：Article

关键词：hypertrophic cardiomyopathy; nonsustained ventricular tachycardia; reverse septal curvature; sudden cardiac death

摘要："Sudden cardiac death (SCD) is associated with nonsustained ventricular tachycardia (NSVT) in patients with hypertrophic cardiomyopathy (HCM). Recently, differences regarding septal morphology have been reported, with an increased probability of sudden death in patients with HCM who had reverse septal curvature (RSC). This study aimed to examine the relation between RSC and NSVT in HCM. A total of 138 patients with HCM were enrolled. Of 138 patients, 47 (34.1%) were diagnosed with RSC and 42 patients (30.4%) had NSVT. Compared with the non-RSC group, those with RSC were much youn-ger and had an increased incidence of NSVT, thicker septal thickness, larger mass, and a higher proportion of HCM or SCD family history. Furthermore, patients with RSC had a higher risk of SCD according to the European Society of Cardiology calculator (2.5 [1.6 to 4.6] vs 1.6 [1.1 to 2.3] [%/5 years], p <0.001). The multivariate analysis showed that RSC was a strong and independent risk factor for NSVT (odds ratio 2.756, 95% confidence interval 1.164 to 6.525, p = 0.021). In conclusion, the presence of RSC in patients with HCM is independently associated with NSVT. Further studies are needed to evaluate the role of RSC as a risk factor for SCD in this population. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http:// creativecommons.org/licenses/by-nc/4.0/) (Am J Cardiol 2024;210:195-200)"

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