Diagnostic Accuracy of Liver and Spleen Stiffness in Magnetic Resonance Elastography for the Detection of Gastroesophageal Varices: A Systematic Review and Meta-Analysis

作者全名："Zheng, You; Huang, Kaifeng; He, Xiaojing; Chen, Tianwu; Jiang, Wei; Zhou, Jun; Liu, Yangyang; Guo, Dajing"

作者地址："[Zheng, You; He, Xiaojing; Chen, Tianwu; Jiang, Wei; Zhou, Jun; Liu, Yangyang; Guo, Dajing] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, 74 Linjiang Rd, Chongqing 400010, Peoples R China; [Huang, Kaifeng] Chongqing Univ, Canc Hosp, Dept Ultrasound, Chongqing 400044, Peoples R China"

通信作者："Guo, DJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：DIAGNOSTICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001117714600001

JCR分区：Q1

影响因子：3

年份：2023

卷号：13

期号：23

开始页：　

结束页：　

文献类型：Review

关键词：magnetic resonance elastography; liver stiffness; spleen stiffness; gastroesophageal varices; meta-analysis

摘要："Background: The aim of this meta-analysis was to assess the performance of magnetic resonance elastography (MRE) in detecting gastroesophageal varices (GEV) in patients with chronic liver disease (CLD). Methods: A literature search in English and Chinese databases such as PubMed, EMBASE, Cochrane Library, Web of Science, and China National Knowledge Infrastructure was conducted. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) of the summary receiver-operating characteristic (SROC) curve with a 95% CI were calculated. A quality analysis of the included study was conducted using the QUADAS-2 tool, and a meta-analysis was performed using Stata16. The clinical practical value of MRE in detecting GEV was evaluated using the Fagan plot. Heterogeneity across studies was explored through meta-regression and subgroup analyses. Results: A total of nine relevant articles that compared liver stiffness (LS) or spleen stiffness (SS) using MRE with esophagogastroduodenoscopy (EGD) to detect the existence of GEV were identified. The pooled summary sensitivity, specificity, PLR, NLR, and DOR of LS or SS for the detection of GEV were 81% (95% CI: 74%, 87%), 72% (95% CI: 62%, 80%), 2.89 (95% CI: 2.12, 3.94), 0.26 (95% CI: 0.19, 0.36), and 10.91 (95% CI: 6.53, 18.24), respectively. The year of publication, study design, and MR equipment are the sources of heterogeneity. There was no significant difference in the publication bias (p > 0.05). Conclusions: Based on these findings, MRE demonstrates good diagnostic accuracy for detecting GEV in patients with CLD."

基金机构：Chongqing Medical Scientific Research Project

基金资助正文：No Statement Available