Negligible effect of vitamin D supplementation on exacerbation in patients with chronic obstructive pulmonary disease: meta-analysis

作者全名："Hua, Ye; Jiang, Ting; Feng, Jiangyi; Zou, Mi"

作者地址："[Hua, Ye; Feng, Jiangyi] Chongqing Univ, Dept Gen Surg, Chongqing Emergency Med Ctr, Cent Hosp, Chongqing, Peoples R China; [Jiang, Ting] Chongqing Univ, Dept Blood Transfus, Chongqing Emergency Med Ctr, Cent Hosp, Chongqing, Peoples R China; [Zou, Mi] Chongqing Med Univ, Branch 1, Resp Dept, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Zou, M (通讯作者)，Chongqing Med Univ, Branch 1, Resp Dept, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：BIOCHEMIA MEDICA

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001121004900013

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：33

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：chronic obstructive pulmonary disease; vitamin D deficiency; disease progression; meta-analysis

摘要："Introduction: The focus of this meta-analysis was how vitamin D supplementation influences exacerbations in patients with chronic obstructive pulmonary disease (COPD) and vitamin D deficiency (VDD). Materials and methods: Cochrane Library, Web of Science, Embase, and PubMed databases have been systematically searched in an attempt to collect randomized controlled trials related to vitamin D supplementation in COPD patients with VDD published in English available by July 2022. Primary outcome indicators included the mean number of exacerbation and rate of exacerbation. Secondary outcome indicators included forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC) ratio, and serum 25-hydroxyvitamin D (25(OH)D) concentration. Results: Five studies involving 522 COPD patients with VDD (defined as 25(OH)D < 50 nmol/L) were included, among them 61 were severely deficient in vitamin D (25(OH)D < 25 nmol/L). The results showed that vitamin D supplementation did not decrease the mean number of exacerbation (standardized mean difference (SMD): - 0.10, 95% CI: - 0.29 to 0.09) and the rate of exacerbation (relative risk (RR): 0.89, 95% CI: 0.76 to 1.04, P = 0.179). Also, its effect on FEV1 (SMD: - 0.06, 95% CI: - 0.30 to 0.17) and FEV1/FVC (SMD: -0.10, 95% CI: - 0.48 to 0.27) remained negligible. However, it could increase the serum 25(OH)D concentration (SMD: 2.44, 95 CI%: 2.20 to 2.68, P < 0.001). Conclusions: The effects of vitamin D supplementation on decreasing exacerbation and improving pulmonary function were not significant."

基金机构：　

基金资助正文：