"Solitary lung adenocarcinoma: follow-up CT, pathological-molecular characteristics, and surgical prognosis for different morphological classifications"

作者全名："Liao, Hong-fan; Huang, Xing-tao; Li, Xian; Lv, Fa-jin; Luo, Tian-you; Li, Qi"

作者地址："[Liao, Hong-fan; Lv, Fa-jin; Luo, Tian-you; Li, Qi] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Liao, Hong-fan] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Huang, Xing-tao] Fifth Peoples Hosp Chongqing, Dept Radiol, Chongqing 400062, Peoples R China; [Li, Xian] Chongqing Med Univ, Dept Pathol, Chongqing, Peoples R China"

通信作者："Li, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：INSIGHTS INTO IMAGING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001122368200001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Lung adenocarcinoma; Computed tomography; Gene mutation; Histological subtype; Prognosis

摘要："Objective To investigate the dynamic changes during follow-up computed tomography (CT), histological subtypes, gene mutation status, and surgical prognosis for different morphological presentations of solitary lung adenocarcinomas (SLADC).Materials and methods This retrospective study compared dynamic tumor changes and volume doubling time (VDT) in 228 patients with SLADC (morphological types I-IV) who had intermittent growth during follow-ups. The correlation between the morphological classification and histological subtypes, gene mutation status, and surgical prognosis was evaluated.Results Among the 228 patients, 66 (28.9%) were classified as type I, 123 (53.9%) as type II, 16 (7%) as type III, and 23 (10.1%) as type IV. Type I had the shortest VDT (254 days), followed by types IV (381 days) and III (501 days), and then type II (993 days) (p < 0.05 each). Type I had a greater proportion of solid/micropapillary-predominant pattern than type II, and the lepidic-predominant pattern was more common in type II and III than in type I (p < 0.05 each). Furthermore, type II and IV SLADCs were correlated with positive epidermal growth factor receptor mutation (p < 0.05 each). Lastly, the Kaplan-Meier curves showed that the disease-free survival was longest for patients with type II tumors, followed by those with type III and IV tumors, and then those with type I tumors (p < 0.001 each).Conclusion A good understanding of the natural progression and pathological-molecular characteristics of different morphological SLADC types can help make accurate diagnoses, develop individual treatment strategies, and predict patient outcomes."

基金机构：Joint project of Chongqing Health Commission and Science and Technology Bureau

基金资助正文：No Statement Available