Genome and proteomic analysis of risk factors for fatal outcome in children with severe community-acquired pneumonia caused by human adenovirus 7

作者全名："Wei, Jianhua; Zang, Na; Zhang, Jing; He, Yu; Huang, Haixia; Liu, Xiangyu; Xu, Ximing; Ren, Luo; Deng, Yu; Wu, Jianguo; Seto, Donald; Zhong, Wen; Zhang, Qiwei; Liu, Enmei"

作者地址："[Wei, Jianhua; Zang, Na; Deng, Yu; Liu, Enmei] Chongqing Med Univ, Dept Resp Med, Childrens Hosp, Chongqing 400014, Peoples R China; [Wei, Jianhua; Zang, Na; He, Yu; Huang, Haixia; Liu, Xiangyu; Xu, Ximing; Ren, Luo; Deng, Yu; Liu, Enmei] Chongqing Med Univ, Minist Educ, Childrens Hosp, Key Lab Child Dev & Disorders, Chongqing, Peoples R China; [Wei, Jianhua; Zang, Na; He, Yu; Huang, Haixia; Liu, Xiangyu; Xu, Ximing; Ren, Luo; Deng, Yu; Liu, Enmei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Chongqing, Peoples R China; [Wei, Jianhua; Zang, Na; He, Yu; Huang, Haixia; Liu, Xiangyu; Xu, Ximing; Ren, Luo; Deng, Yu; Liu, Enmei] Chongqing Med Univ, Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Wei, Jianhua; Zang, Na; He, Yu; Huang, Haixia; Liu, Xiangyu; Xu, Ximing; Ren, Luo; Deng, Yu; Liu, Enmei] Chongqing Med Univ, Chongqing Key Lab Pediat, Childrens Hosp, Chongqing, Peoples R China; [Zhang, Jing; Wu, Jianguo; Zhang, Qiwei] Jinan Univ, Coll Life Sci & Technol, Inst Med Microbiol, Minist Educ,Key Lab Viral Pathogenesis & Infect P, Guangzhou, Peoples R China; [Huang, Haixia] Chongqing Med Univ, Dept Intens Care Unit, Childrens Hosp, Chongqing, Peoples R China; [Seto, Donald] George Mason Univ, Bioinformat & Computat Biol Program, Sch Syst Biol, Manassas, VA USA; [Zhong, Wen] Linkoping Univ, Dept Biomed & Clin Sci BKV, Sci Life Lab, Linkoping, Sweden; [Zhong, Wen] Karolinska Inst, Dept Neurosci, Stockholm, Sweden; [Zhang, Qiwei] Southern Med Univ, Sch Publ Hlth, BSL 3 Lab Guangdong, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Peoples R China"

通信作者："Liu, EM (通讯作者)，Chongqing Med Univ, Dept Resp Med, Childrens Hosp, Chongqing 400014, Peoples R China.; Zhang, QW (通讯作者)，Jinan Univ, Coll Life Sci & Technol, Inst Med Microbiol, Guangzhou 510632, Guangdong, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001124416600002

JCR分区：Q1

影响因子：6.8

年份：2023

卷号：95

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：human adenovirus 7; mortality; risk factors; severe community-acquired pneumonia

摘要："Introduction: Human adenovirus 7 (HAdV-7) is an important viral pathogen of severe pneumonia in children and a serious threat to health. Methods: A cohort of 45 pediatric patients diagnosed with HAdV-7-associated severe pneumonia and admitted to the Pediatric Intensive Care Unit at the Children's Hospital of Chongqing Medical University from May 2018 to January 2020 were included. Risk factors of death were analyzed by the Cox proportional risk mode with Clinical data, serum, and nasopharyngeal aspirate adenovirus load, Genome analysis, Olink proteomics, and cytokine profile between dead and surviving patients were also analyzed. Results: A total of 45 children with a median age of 12.0 months (interquartile range [IQR]: 6.5, 22.0) were included (female 14), including 14 (31.1%) who died. High serum viral load was an independent risk factor for mortality (hazard ratio [HR] = 2.16, 95% confidence interval [CI], 1.04-4.49, p = 0.039). BTB and CNC homology 1 (BACH1), interleukin-5 (IL-5), and IL-9 levels were significantly correlated with serum viral load (p = 0.0400, 0.0499, and 0.0290; r = 0.4663, 0.3339, and -0.3700, respectively), with significant differences between the dead and survival groups (p = 0.021, 0.001, and 0.021). Conclusions: Severe cytokine storm-associated high serum viral load after HAdV-7 infection may be the main mechanism responsible for poor prognosis in children."

基金机构：General Project of National Natural Science Foundation of China [32071123]; Chongqing Science and Health Joint project [2020FYYX148]; Ministry of Education Key Laboratory of Child Development and Disorders [YBRP-2021XX]; National Natural Science Foundation of China [32170139]; CQMU Program for Youth Innovation in Future Medicine [W0178]; Chongqing high-end medicine for young and middle-aged people Talent Program [CQYC202203091217]

基金资助正文："General Project of National Natural Science Foundation of China, Grant/Award Number: 32071123; Chongqing Science and Health Joint project, Grant/Award Number: 2020FYYX148; Youth Basic Research Project from the Ministry of Education Key Laboratory of Child Development and Disorders, Grant/Award Number: YBRP-2021XX; National Natural Science Foundation of China, Grant/Award Number: 32170139; CQMU Program for Youth Innovation in Future Medicine, Grant/Award Number: W0178; Chongqing high-end medicine for young and middle-aged people Talent Program, Grant/Award Number: CQYC202203091217"