Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population

作者全名："Li, Wei; Zhang, Hua; Ren, Ao; Fan, Wei; Qin, Qiong; Zhao, Ling; Ma, Ruidong; Peng, Qiufeng; Luo, Shiqiao"

作者地址："[Li, Wei; Zhang, Hua; Ren, Ao; Qin, Qiong; Zhao, Ling; Ma, Ruidong; Peng, Qiufeng; Luo, Shiqiao] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Fan, Wei] Chongqing Sixth Peoples Hosp, Dept Hepatobiliary Surg, Chongqing, Peoples R China"

通信作者："Luo, SQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001124416600032

JCR分区：Q1

影响因子：12.7

年份：2023

卷号：95

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：causal relationship; GWAS; HBV; Mendelian randomization; SLE

摘要："The relationship between systemic lupus erythematosus (SLE) and hepatitis B virus (HBV) infection is still unclear. We conducted a two-sample Mendelian randomization (MR) analysis using summary statistics from genome-wide association studies for SLE and HBV infection in individuals of East Asian ancestry. The inverse-variance weighted (IVW) method, weighted median (WM) method, and MR-Egger method were used to estimate the causal effect of SLE on HBV infection. Additionally, we performed a multivariable MR analysis adjusting for the effects of body mass index and rheumatoid arthritis. This MR study included a total of 225106 individuals of East Asian ancestry, comprising 5616 cases and 219490 controls. The IVW method (OR: 0.79, p=3.34E-08) and the WM method (OR: 0.79, p=9.09E-06) revealed a causal relationship between genetically predicted SLE and a low risk of HBV infection. The multivariable MR analysis still suggested a low risk of HBV infection associated with SLE (OR: 0.83, p=2.89E-06). Our MR analysis supports a causal relationship between SLE and a low risk of HBV infection in individuals of East Asian ancestry."

基金机构：Natural Science Foundation of Chongqing [cstsc2013jcjyA10105]; National Natural Science Foundation of China [H1006/30972789]

基金资助正文："Natural Science Foundation of Chongqing, Grant/Award Number: cstsc2013jcjyA10105; National Natural Science Foundation of China, Grant/Award Number: H1006/30972789"