Assessment of bidirectional relationships between multiple sclerosis and epilepsy: A two-sample Mendelian randomization study

作者全名："Zuo, Hongzhou; Peng, Li; Li, Wei; Wang, Yuzhu; Du, Xinyi; Zou, Xiaoya; Dong, Zhaoying; Yi, Li; Yin, Huimei; Quan, Fengying; Cheng, Oumei"

作者地址："[Zuo, Hongzhou; Peng, Li; Wang, Yuzhu; Du, Xinyi; Zou, Xiaoya; Dong, Zhaoying; Yi, Li; Yin, Huimei; Quan, Fengying; Cheng, Oumei] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China; [Peng, Li] Youyang Cty Peoples Hosp, Dept Neurol, Chongqing 409899, Peoples R China; [Li, Wei] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Quan, FY; Cheng, OM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China."

来源：MULTIPLE SCLEROSIS AND RELATED DISORDERS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001125602000001

JCR分区：Q2

影响因子：4

年份：2024

卷号：81

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Multiple sclerosis; Epilepsy; Inflammation; Mendelian randomization; GWAS

摘要："Background and objective: Epidemiological studies indicate that multiple sclerosis (MS) is associated with epilepsy. However, the causality and directionality of this association remain under-elucidated. This study aimed to reveal the causality between MS and epilepsy. Methods: A two-sample Mendelian randomization (MR) analysis was performed by using summarized statistics derived from large genome-wide association studies of MS and epilepsy. We used the inverse variance weighted method as the primary approach, and then four other MR methods to bidirectionally evaluate the causality of the association between MS and epilepsy. Additional sensitivity analyses were performed to measure the robustness of the findings. Results: Genetically predicted MS was positively correlated with developing all epilepsy [odds ratio (OR) = 1.027 (1.003-1.051), P = 0.028] and generalized epilepsy [OR = 1.050 (1.008-1.094), P = 0.019]. In the reverse MR analysis, all epilepsy [OR = 1.310 (1.112-1.543), P = 0.001], generalized epilepsy [OR = 1.173 (1.010-1.363), P = 0.037], and focal epilepsy [OR = 1.264 (1.069-1.494), P = 0.006] elevated the risk of developing MS. The result remained robust and congruous across all sensitivity analyses conducted. Conclusions: MS is potentially associated with a higher risk of developing epilepsy. Furthermore, epilepsy may be a causal determinant of MS risk. These findings may further the understanding of the interaction of the two conditions."

基金机构：Chongqing medical scientific research project [2022MSXM055]

基金资助正文："This work was supported by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau, 2022MSXM055)."