The association of serum choline concentrations with the risk of cancers: a community-based nested case-control study

作者全名："Li, Wenqiang; Li, Chong; Liu, Tong; Song, Yun; Chen, Ping; Liu, Lishun; Wang, Binyan; Qu, Jun"

作者地址："[Li, Wenqiang; Qu, Jun] Aerosp Ctr Hosp, Dept Gen Surg, Beijing 100038, Peoples R China; [Li, Chong] Chongqing Med Univ, Dazu Hosp, Dept Oncol, Chongqing 402360, Peoples R China; [Liu, Tong] Capital Med Univ, Affiliated Beijing Shijitan Hosp, Dept Gastrointestinal Surg Clin Nutr, Beijing 100038, Peoples R China; [Song, Yun; Chen, Ping; Liu, Lishun; Wang, Binyan] Shenzhen Evergreen Med Inst, Shenzhen 518000, Peoples R China"

通信作者："Qu, J (通讯作者)，Aerosp Ctr Hosp, Dept Gen Surg, Beijing 100038, Peoples R China.; Wang, BY (通讯作者)，Shenzhen Evergreen Med Inst, Shenzhen 518000, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001126327000047

JCR分区：Q1

影响因子：3.8

年份：2023

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Few studies have been designed to investigate the effect of serum choline on the risk of incident cancer. This study aims to explore the association between serum choline and the risk of new-onset cancer. We conducted a case-control study, including 199 patients with incident cancer and 199 matched controls during a median of 3.9 years of follow-up, nested within the China Stroke Primary Prevention Trial. Cubic spline regression (RCS) and conditional logistic regression analysis was used to assess the association of serum choline and incident cancer risk. We observed a positive dose-response association between serum choline levels and the risk of overall (p for overall = 0.046) and digestive system cancer (p for overall = 0.039). Compared with patients with the lowest choline levels (Q1 group), patients in the highest levels of choline (Q4) had a 3.69-fold and 6.01-fold increased risk of overall (OR = 3.69, 95% CI 1.17-11.63) and digestive system cancer (OR = 6.01, 95% CI 1.14-31.67). Elevated choline levels (per SD, 11.49 mu g/mL) were associated with a higher risk of overall cancer among participants who were older, male, and smokers in the subgroup analyses. We found a positive association between elevated levels of serum choline with increased risk of incident cancer. Our findings have critical clinical implications for cancer prevention and diagnosis.Trial registration CSPPT, NCT00794885. Registered: November 20, 2008. https://www.clinicaltrials.gov/ct2/show/study/NCT00794885https://www.clinicaltrials.gov/ct2/show/study/NCT00794885."

基金机构：　

基金资助正文：