Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis

作者全名："Zhao, Min; Wang, Lixing; Wang, Xingyu; He, Juan; Yu, Kuai; Li, Dan"

作者地址："[Zhao, Min; Yu, Kuai; Li, Dan] Chongqing Med Univ, Dept Pathol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Min; Wang, Lixing; Wang, Xingyu; He, Juan; Li, Dan] Chongqing Med Univ, Dept Pathol, Chongqing, Peoples R China; [Zhao, Min; Yu, Kuai; Li, Dan] Chongqing Med Univ, Mol Med Diagnost & Testing Ctr, Chongqing, Peoples R China; [Yu, Kuai] Chongqing Med Univ, Yongchuan Hosp, Dept Pathol, Chongqing, Peoples R China"

通信作者："Li, D (通讯作者)，Chongqing Med Univ, Dept Pathol, Affiliated Hosp 1, 1 Yi Xue Yuan Rd, Chongqing 400016, Peoples R China."

来源：TUMORI JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001137165300001

JCR分区：Q4

影响因子：1.9

年份：2024

卷号：110

期号：4

开始页：227

结束页：240

文献类型：Review

关键词：diffuse large B cell lymphoma; prognostic biomarker; tumor microenvironment; systematic review; meta-analysis

摘要："The microenvironment of diffuse large B-cell lymphoma (DLBCL) is composed of various components, including immune cells and immune checkpoints, some of which have been correlated with the prognosis of DLBCL, but their results remain controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between the microenvironment and prognosis in DLBCL. We searched PubMed, Web of Science, and EMBASE for relevant articles between 2001 and 2022. Twenty-five studies involving 4495 patients with DLBCL were included in the analysis. This meta-analysis confirmed that high densities of Foxp3+Tregs and PD-1+T cells are good indicators for overall survival (OS) in DLBCL, while high densities of programmed cell death protein ligand1(PD-L1)-positive expression cells and T-cell immunoglobulin-and mucin domain-3-containing molecule 3 (TIM-3)-positive expression tumor-infiltrating cells (TILs) play a contrary role in OS. Additionally, higher numbers of T-cell intracytoplasmic antigen-1(TIA-1)-positive expression T cells imply better OS and progression-free survival (PFS), while high numbers of lymphocyte activation gene(LAG)-positive expression TILs predict bad OS and PFS. Various non-tumoral cells in the microenvironment play important roles in the prognosis of DLBCL."

基金机构：Chongqing Medical University [ZHYX202104]

基金资助正文："The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by Key Projects of Chongqing Medical University (No. ZHYX202104)."