Do patients with cN0 oral squamous cell carcinoma benefit from elective neck dissection? A large-scale population-based study

作者全名："Wu, Qiuyu; Xia, Yuanhang; Qiu, Ling; Wen, Shuqiong; Li, Qunxing; Gao, Xiang; Jiang, Wenrong; Wang, Tao; Ji, Ping; Ou, Zhanpeng"

作者地址："[Wu, Qiuyu; Xia, Yuanhang; Wen, Shuqiong; Jiang, Wenrong; Ji, Ping; Ou, Zhanpeng] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, 426 Songshi North Rd, Chongqing, Peoples R China; [Wu, Qiuyu; Xia, Yuanhang; Wen, Shuqiong; Jiang, Wenrong; Ji, Ping; Ou, Zhanpeng] Chongqing Med Univ, Stomatol Hosp, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Qiu, Ling; Li, Qunxing] Sun Yat Sen Mem Hosp, Dept Oral & Maxillofacial Surg, Guangzhou, Peoples R China; [Gao, Xiang; Wang, Tao] Chongqing Med Univ, Stomatol Hosp, Dept Oral & Maxillofacial Surg, Chongqing, Peoples R China"

通信作者："Ji, P; Ou, ZP (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, 426 Songshi North Rd, Chongqing, Peoples R China.; Ji, P; Ou, ZP (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China."

来源：BMC ORAL HEALTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001137224700005

JCR分区：Q1

影响因子：2.9

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Oral squamous cell carcinoma; Clinical-nodal negative; Elective neck dissection; SEER database; Multiple subgroup analyses; Disease-specific survival; Overall survival

摘要："Background The neck management of clinical-nodal negative (cN0) oral squamous cell carcinoma (OSCC) remains controversial. Elective neck dissection (END) and observation are the main strategies, but it is still not clear who could benefit the most from END. The purpose of this study was to clarify the potential clinical factors that affect the therapeutic value of END and to explore the actual characteristics associated with benefit from END.Methods Patients with cN0 OSCC were identified in the SEER database from 2000 to 2019. 5-year Overall survival (OS) and disease-specific survival (DSS) were analyzed using the Kaplan-Meier method, and the hazard ratios (HRs) for survival were estimated using the Cox regression model. Multiple subgroup analyses of DSS and OS among different factors, comparing END and No END, were performed.Results A total of 17,019 patients with cN0 OSCC were included. The basic survival analysis and Cox regression model showed that END increased the probability of 5-year DSS and OS and was an independent prognostic factor. However, among patients who underwent only primary tumor surgery, no significant differences were found between the END and No END groups in 5-year DSS (P = 0. 585) and OS (P = 0.465). Further subgroup analysis showed that primary sites and T stage, but not other factors, might influence the benefit of END. Significant differences were found for T1 (P < 0.001 for OS) and T2 (P = 0.001 for DSS and < 0.001 for OS) tongue squamous cell carcinoma (TSCC) but not for other primary tumor sites.Conclusion This large-scale retrospective population-based cohort study suggests that not all patients with cN0 OSCC could benefit from END. Patients with cN0 TSCC are recommended to undergo END, especially with early-stage tumors."

基金机构：National Natural Science Foundation of China

基金资助正文：The authors wish to give special thanks for the efforts of the SEER tumor registry team. The authors are also grateful to American Journal Experts (https://www.aje.com) for checking the English of the article.