Common and distinct neural correlates of emotional processing in individuals at familial risk for major depressive disorder and bipolar disorder: A comparative meta-analysis

作者全名："Qin, Kun; Pan, Nanfang; Lei, Du; Zhang, Feifei; Yu, Yifan; Sweeney, John A.; Delbello, Melissa P.; Gong, Qiyong"

作者地址："[Qin, Kun; Pan, Nanfang; Zhang, Feifei; Yu, Yifan; Sweeney, John A.; Gong, Qiyong] Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, West China Hosp, Chengdu 610041, Peoples R China; [Qin, Kun] Hubei Univ Med, Taihe Hosp, Dept Radiol, Shiyan 442000, Peoples R China; [Qin, Kun; Lei, Du; Sweeney, John A.; Delbello, Melissa P.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA; [Pan, Nanfang] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu 610041, Peoples R China; [Lei, Du] Chongqing Med Univ, Coll Med Informat, Chongqing 400016, Peoples R China; [Gong, Qiyong] Sichuan Univ, Dept Radiol, West China Xiamen Hosp, Xiamen 361021, Peoples R China; [Gong, Qiyong] Sichuan Univ, Dept Radiol, West China Xiamen Hosp, Xiamen, Fujian, Peoples R China"

通信作者："Gong, QY (通讯作者)，Sichuan Univ, Dept Radiol, West China Xiamen Hosp, Xiamen, Fujian, Peoples R China."

来源：JOURNAL OF AFFECTIVE DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001143495000001

JCR分区：Q1

影响因子：4.9

年份：2024

卷号：348

期号：　

开始页：97

结束页：106

文献类型：Article

关键词：Mood disorder; Emotion regulation; Magnetic resonance imaging; Meta -analysis; Task; Vulnerability

摘要："Individuals at familial risk for mood disorders exhibit deficits in emotional processing and associated brain dysfunction prior to illness onset. However, such brain-behavior abnormalities related to familial predisposition remain poorly understood. To investigate robust abnormal functional activation patterns during emotional processing in unaffected at-risk relatives of patients with major depressive disorder (UAR-MDD) and bipolar disorder (UAR-BD), we performed a meta-analysis of task-based functional magnetic resonance imaging studies using Seed-based d Mapping (SDM) toolbox. Common and distinct patterns of abnormal functional activation between UAR-MDD and UAR-BD were detected via conjunction and differential analyses. A total of 17 studies comparing 481 UAR and 670 healthy controls (HC) were included. Compared with HC, UAR-MDD exhibited hyperactivation in the parahippocampal gyrus, amygdala and cerebellum, while UAR-BD exhibited para-hippocampal hyperactivation and hypoactivation in the striatum and middle occipital gyrus (MOG). Conjunction analysis revealed shared hyperactivated PHG in both groups. Differential analysis indicated that the activation patterns of amygdala and MOG significantly differed between UAR-MDD and UAR-BD. These findings provide novel insights into common and distinct neural phenotypes for familial risk and associated risk mechanisms in MDD and BD, which may have implications in guiding precise prevention strategies tailored to the family context."

基金机构："National Key R&D Program of China [2022YFC2009900]; National Natural Science Foundation of China [81621003, 81761128023, 82027808, 81820108018]; NIH/NIMH [R01MH112189-01]"

基金资助正文："This study was supported by the National Key R&D Program of China (2022YFC2009900) and the National Natural Science Foundation of China (Grant Nos. 81621003, 81761128023, 82027808 and 81820108018) and NIH/NIMH R01MH112189-01."