A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones

作者全名："Li, Xintao; Xie, Yongpeng; Tang, Lu; Li, Di; Wang, Jun; Sheng, Haibo; Chen, Kaikai; Xiao, Shuwei; Li, Jianye; Yang, Minghui"

作者地址："[Li, Xintao; Yang, Minghui] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Tradit Chinese Med, Beijing, Peoples R China; [Li, Xintao; Tang, Lu] Chinese Peoples Liberat Army PLA Gen Hosp, Med Ctr 3, Dept Urol, Beijing, Peoples R China; [Li, Xintao; Li, Di; Wang, Jun; Sheng, Haibo; Chen, Kaikai; Xiao, Shuwei; Li, Jianye] Air Force Med Univ, Aif Force Med Ctr, Dept Urol, Beijing, Peoples R China; [Xie, Yongpeng] First Affiliated Hosp Chongqing Med Univ, Dept Gastroenterol, Chongqing, Peoples R China"

通信作者："Yang, MH (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Tradit Chinese Med, Beijing, Peoples R China.; Li, JY (通讯作者)，Air Force Med Univ, Aif Force Med Ctr, Dept Urol, Beijing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001147754100001

JCR分区：Q2

影响因子：5.2

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：NAFLD; kidney stone; Mendelian randomization; causality; genome wide association study

摘要："ObjectivesNon-alcoholic fatty liver disease (NAFLD) has been linked to an increased risk of kidney stones in prior observational studies, However, the results are inconsistent, and the causality remains to be established. We aimed to investigate the potential causal relationship between NAFLD and kidney stones using two-sample Mendelian randomization (MR).MethodsGenetic instruments were used as proxies for NAFLD. Summary-level data for the associations of exposure-associated SNPs with kidney stones were obtained from the UK Biobank study (6536 cases and 388,508 controls) and the FinnGen consortium (9713 cases and 366,693 non-cases). MR methods were conducted, including inverse variance weighted method (IVW), MR-Egger, weighted median, and MR-PRESSO. MR-Egger Regression Intercept and Cochran's Q test were used to assess the directional pleiotropy and heterogeneity.ResultscALT-associated NAFLD did not exhibit an association with kidney stones in the Inverse variance weighted (IVW) methods, in both the FinnGen consortium (OR: 1.02, 95%CI: 0.94-1.11, p = 0.632) and the UKBB study (OR: 1.000, 95%CI: 0.998-1.002, p = 0.852). The results were consistent in European ancestry (FinnGen OR: 1.05, 95%CI: 0.98-1.14, p = 0.144, UKBB OR: 1.000, 95%CI: 0.998-1.002, p = 0.859). IVW MR analysis also did not reveal a significant causal relationship between NAFLD and the risk of kidney stone for the other three NAFLD-related traits, including imaging-based, biopsy-confirmed NAFLD, and more stringent biopsy-confirmed NAFLD. The results remained consistent and robust in the sensitivity analysis.ConclusionsThe MR study did not provide sufficient evidence to support the causal associations of NAFLD with kidney stones."

基金机构：National Natural Science Foundation of China10.13039/501100001809

基金资助正文："We sincerely acknowledge the contribution from the MVP Consortium, FinnGen Consortium and UK Biobank consortium for sharing the GWAS summary statistics on the diseases."