Risk factors for anastomotic stenosis after radical resection of rectal cancer: A systematic review and meta-analysis

作者全名："He, Fan; Yang, Fuyu; Chen, Defei; Tang, Chenglin; Woraikat, Saed; Xiong, Junjie; Qian, Kun"

作者地址："[He, Fan; Yang, Fuyu; Chen, Defei; Tang, Chenglin; Woraikat, Saed; Xiong, Junjie; Qian, Kun] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Qian, K (通讯作者)，Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：ASIAN JOURNAL OF SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001155346800001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：47

期号：1

开始页：25

结束页：34

文献类型：Review

关键词：Radical resection of rectal cancer; Anastomotic stenosis; Meta-analysis

摘要："Radical resection of rectal cancer is a safe and effective treatment, but there remain several complications related to anastomosis. We aimed to assess the risk factors and incidence of rectal anastomotic stenosis (AS) after rectal cancer resection. We conducted a systematic review and meta-analysis after searching PubMed, Embase, Web of Science, and Medline databases from inception until May 2023. Data are reported as the combined odds ratio (OR) for categorical variables and the weighted mean difference (WMD) for continuous variables. Six hundred and fifty-nine studies were retrieved, nine (3031 patients) of which were included in the meta-analysis. Young age (WMD = -3.09, P = 0.0002), male sex (OR = 1.53, P = 0.0002), smoking (OR = 1.54, P = 0.009), radiotherapy (OR = 2.34, P = 0.0002), protective stoma (OR = 2.88, P = 0.007), intersphincteric resection surgery (OR = 6.28, P = 0.05), anastomotic fistula (OR = 3.72, P = 0.003), and anastomotic distance (WMD = -3.11, P = 0.0006) were identified as factors that increased the risk of AS, while staple (OR = 0.39, P < 0.001) was a protective factor. The incidence of AS after rectal cancer resection was approximately 17% (95% CI: 13%-21%). We identified eight risk factors and one protective factor associated with AS after rectal cancer resection. These factors may be combined in future studies to develop a more comprehensive and accurate prediction model related to AS after rectal cancer resection. (c) 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/)."

基金机构：Natural Science Foundation of Chongqing [CSTC2021JCYJ-MSXMX0286]

基金资助正文："<BOLD>Funding</BOLD> This research was supported by Natural Science Foundation of Chongqing [number CSTC2021JCYJ-MSXMX0286] . The funders were not involved in the design of the study, analysis, interpreta-tion of the data, the writing of this paper, or the decision to submit it for publication."