Prognostic factors in extensive-stage small cell lung cancer patients with organ-specific metastasis: unveiling commonalities and disparities

作者全名："Wu, Yuanli; Zhang, Jing; Zhou, Weiying; Yuan, Zhongzhen; Wang, Hongmei"

作者地址："[Wu, Yuanli; Zhou, Weiying; Wang, Hongmei] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China; [Zhang, Jing] Chongqing Univ, Canc Hosp, Dept Pathol, Chongqing, Peoples R China; [Yuan, Zhongzhen] Chongqing Univ, Canc Hosp, Dept Pharm, 181 Hanyu Rd, Chongqing, Peoples R China; [Wang, Hongmei] Chongqing Med Univ, Dept Pharm, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Wang, HM (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China.; Yuan, ZZ (通讯作者)，Chongqing Univ, Canc Hosp, Dept Pharm, 181 Hanyu Rd, Chongqing, Peoples R China.; Wang, HM (通讯作者)，Chongqing Med Univ, Dept Pharm, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001155888400003

JCR分区：Q3

影响因子：2.7

年份：2024

卷号：150

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：Small cell lung cancer; Metastasis; Survival; SEER; Nomogram

摘要："BackgroundThis study aimed to identify shared and distinct prognostic factors related to organ-specific metastases (liver, lung, bone, and brain) in extensive-stage small cell lung cancer (ES-SCLC) patients, then construct nomograms for survival prediction.MethodsPatient data for ES-SCLC were from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2019. Kaplan-Meier analysis was applied to estimate overall survival (OS), and Cox regression was used to identify prognostic factors. A Venn diagram was utilized to distinguish common and unique prognostic factors among the variables assessed. These identified prognostic factors were used to formulate a nomogram, and its predictive accuracy and reliability were evaluated using C-indexes, calibration curves, and receiver operating characteristic (ROC) curves.ResultsA total of 24,507 patients diagnosed with ES-SCLC exhibiting metastases to the liver, lung, bone, and brain were included. The 6-month, 1-year, and 2-year OS rates were 46.1%, 19.7%, and 5.0%, respectively. Patients with liver metastasis demonstrated the most unfavorable prognosis, with a 1-year OS rate of 14.5%, while those with brain metastasis had a significantly better prognosis with a 1-year OS rate of 21.6%. The study identified seven common factors associated with a poor prognosis in ES-SCLC patients with organ-specific metastases: older age, male sex, unmarried status, higher T stage, presence of other metastases, and combination radiotherapy and chemotherapy. Furthermore, specific prognostic factors were identified for patients with metastasis to the liver, bone, and brain, including paired tumors, lack of surgical treatment at the primary site, and household income, respectively. To facilitate prognostic predictions, four nomograms were developed and subsequently validated. The performance of these nomograms was assessed using calibration curves, C-indexes, and the area under the curve (AUC), all of which consistently indicated good predictive accuracy and reliability.ConclusionsPatients diagnosed with ES-SCLC with organ-specific metastases revealed shared and distinct prognostic factors. The nomograms developed from these factors demonstrated good performance and can serve valuable clinical tools to predict the prognosis of ES-SCLC patients with organ-specific metastases."

基金机构：　

基金资助正文：