Effects of nonalcoholic fatty liver disease on sarcopenia: evidence from genetic methods

作者全名："Yuan, Jiaqin; Zhang, Jinglin; Luo, Qiang; Peng, Lipeng"

作者地址："[Yuan, Jiaqin; Peng, Lipeng] Second Peoples Hosp Yibin, Dept Orthoped, Yibin, Sichuan, Peoples R China; [Zhang, Jinglin] Yibin Ctr Dis Control & Prevent, Dept Occupat Dis, Yibin, Sichuan, Peoples R China; [Luo, Qiang] Chongqing Med Univ, Childrens Hosp, Dept Cardiol, Chongqing, Peoples R China"

通信作者："Peng, LP (通讯作者)，Second Peoples Hosp Yibin, Dept Orthoped, Yibin, Sichuan, Peoples R China.; Luo, Q (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Cardiol, Chongqing, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001156412600022

JCR分区：Q1

影响因子：3.8

年份：2024

卷号：14

期号：1

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结束页：　

文献类型：Article

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摘要："With the aging of the population, sarcopenia has become more common. Studies have shown a broad association between liver disease and sarcopenia. However, this link remains unclear. Our study explored the link between NAFLD and sarcopenia and predicting the pathogenesis. To begin, we investigated the causal relationship and genetic correlation between them using MR and LDSC. Second, each GWAS was annotated by MAGMA. The annotated genes were analyzed for pleiotropy using the PLACO approach. Finally, functional analysis was conducted on the identified pleiotropic genes. We observed a significant genetic correlation between NAFLD and sarcopenia. Subsequently, we conducted gene-level pleiotropy analysis using PLACO and identified a total of 153 genes with pleiotropic effects. Functional analysis revealed enrichment of these genes in various tissues, including pancreas, liver, heart, blood, brain, and muscle, with involvement in cellular regulation, intracellular function, and antigen response. Moreover, our MR analysis provided evidence of a causal relationship between NAFLD and sarcopenia. Our study has discovered the genetic and causal relationships between NAFLD and sarcopenia, providing further insights into their pathophysiological mechanisms. The identification of pleiotropic genes also offers potential targets for future drug therapies aimed at controlling or treating NAFLD and sarcopenia."

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