Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies

作者全名："Xing, Yuhan; Yang, Xinmeng; Li, Zhaoyinqian; Zou, Qiyuan; Yang, Ping; Wang, Qinzheng; Ni, Wei; Wu, Dongze; Li, Guoju"

作者地址："[Xing, Yuhan] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen 518107, Guangdong, Peoples R China; [Xing, Yuhan] Chinese Univ Hong Kong, Prince Wales Hosp, Fac Med, Dept Paediat,Shatin, Hong Kong, Peoples R China; [Xing, Yuhan; Yang, Xinmeng; Yang, Ping; Wang, Qinzheng; Ni, Wei; Li, Guoju] Qingdao Univ, Qingdao Women & Childrens Hosp, Qingdao, Shandong, Peoples R China; [Li, Zhaoyinqian] Southwest Med Univ, Dept Lab Med, Affiliated Hosp, Luzhou, Sichuan, Peoples R China; [Li, Zhaoyinqian] Sichuan Prov Engn Technol Res Ctr Mol Diag Clin Di, Luzhou, Sichuan, Peoples R China; [Li, Zhaoyinqian] Mol Diag Clin Dis Key Lab Luzhou, Luzhou, Sichuan, Peoples R China; [Zou, Qiyuan] Chongqing Med Univ, Dept Otorhinolaryngol, Childrens Hosp, Chongqing, Peoples R China; [Wu, Dongze] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Rheumatol & Immunol, Chengdu, Sichuan, Peoples R China"

通信作者："Li, GJ (通讯作者)，Qingdao Univ, Qingdao Women & Childrens Hosp, Qingdao, Shandong, Peoples R China.; Wu, DZ (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Rheumatol & Immunol, Chengdu, Sichuan, Peoples R China."

来源：CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001156701400001

JCR分区：Q1

影响因子：8.4

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Asthma; Allergy; Birth cohort; Child; China; Rural

摘要："Asthma and allergies are some of the most common chronic disorders affecting children, the prevalence of which has been increasing in countries and regions undergoing rapid development like China. To curb the rising tide of allergies and safeguard the health of future generations, it is of critical importance to understand how asthma inception is influenced by factors acting at different life stages. Birth cohorts represent a powerful tool to investigate the temporal sequence of exposures along the natural course of asthma. We examined recent evidence on birth cohort studies of asthma and allergic diseases and evaluated their strengths and weaknesses. Essential elements for a successful birth cohort are proposed to further elucidate asthma etiology and pathogenies. Initiating new cohorts in understudied populations with the application of advanced analytical approaches will be needed. Moreover, fostering collaborative networks using standardized methodologies should be prioritized to enable integration of findings across diverse cohorts. There remains an urgent and unmet need to further translate the seminal findings from asthma birth cohort studies into targeted primary prevention strategies to eradicate the disease."

基金机构：National Natural Science Foundation of China

基金资助正文："The authors would like to heartfully thank Prof. Gary W.K. Wong from The Chinese University of Hong Kong, Prof. Jing Li from Guangzhou Medical University, and Prof. Bianca Schaub from LMU Munich for their valuable insights during the preparation of this manuscript."