Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China

作者全名："Qi, Xiujie; Yang, Ting; Chen, Jie; Chen, Li; Dai, Ying; Wei, Hua; Jia, Feiyong; Wu, Lijie; Hao, Yan; Li, Ling; Zhang, Jie; Ke, Xiaoyan; Yi, Mingji; Hong, Qi; Chen, Jinjin; Fang, Shuanfeng; Wang, Yichao; Wang, Qi; Jin, Chunhua; Li, Tingyu"

作者地址："[Qi, Xiujie; Yang, Ting; Chen, Jie; Chen, Li; Dai, Ying; Wei, Hua; Li, Tingyu] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Childhood Nutr & Hlth,Childrens, Minist Educ,Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China; [Jia, Feiyong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun 130021, Peoples R China; [Wu, Lijie] Harbin Med Univ, Dept Childrens & Adolescent Hlth, Publ Hlth Coll, Harbin 150081, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430030, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou 570100, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Xian 710003, Peoples R China; [Ke, Xiaoyan] Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing 210013, Peoples R China; [Yi, Mingji] Qingdao Univ, Affiliated Hosp, Dept Child Hlth Care, Qingdao 266003, Peoples R China; [Hong, Qi] Maternal & Child Hlth Care Hosp Baoan, Shenzhen 518133, Peoples R China; [Chen, Jinjin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Childrens Healthcare, Shanghai 200040, Peoples R China; [Fang, Shuanfeng] Affiliated Zhengzhou Univ, Childrens Hosp, Zhengzhou 450053, Peoples R China; [Wang, Yichao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang 618000, Sichuan, Peoples R China; [Jin, Chunhua] Capital Inst Pediat, Dept Children Hlth Care, Beijing 100020, Peoples R China"

通信作者："Li, TY (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Childhood Nutr & Hlth,Childrens, Minist Educ,Key Lab Child Dev & Disorders, Chongqing 400014, Peoples R China."

来源：RESEARCH IN AUTISM SPECTRUM DISORDERS

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001157684300001

JCR分区：Q1

影响因子：2.2

年份：2024

卷号：111

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Vitamin D; Multivitamin; Pregnancy; Autism spectrum disorder; Symptom; Children

摘要："Background: We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods: This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBSR2016). Results: Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [beta = -1.342 (-2.275, -0.409), P = 0.005] and communication warning behavior [beta = -6.631 (-9.899, -3.363), P < 0.001] scores and higher personal -social quotient [beta = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions: This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal -social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms"

基金机构：National Natural Science Foundation of China [81771223]; Chongqing Science and Technology Bureau Research Project [cstc2019jscx-msxmX0217]; Chongqing Medical Scientific Research Project [2019MSXM037]

基金资助正文："<B>Funding</B> This work was supported by the National Natural Science Foundation of China (No. 81771223) , Chongqing Science and Technology Bureau Research Project (cstc2019jscx-msxmX0217) , and Chongqing Medical Scientific Research Project (2019MSXM037) ."