Facile Synthesis of Basic Copper Carbonate Nanosheets for Photoacoustic Imaging-Guided Tumor Apoptosis and Ferroptosis and the Extension Exploration of the Synthesis Method

作者全名："Zhao, Sheng; Wang, Jianxin; Lu, Shi-Yu; Wang, Jingjing; Chen, Ziqun; Sun, Yihao; Xu, Ting; Liu, Yanqing; He, Liang; Chen, Chunmei; Ouyang, Yi; Tan, Yixin; Chen, Yan; Zhou, Benqing; Cao, Yang; Liu, Hui"

作者地址："[Zhao, Sheng; Wang, Jingjing; Sun, Yihao; Xu, Ting; Liu, Yanqing; He, Liang; Chen, Chunmei; Ouyang, Yi; Tan, Yixin; Chen, Yan; Liu, Hui] Southwest Univ, Minist Educ, Sch Mat & Energy, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China; [Wang, Jianxin; Chen, Ziqun; Cao, Yang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Wang, Jianxin] Harbin Med Univ, Affiliated Hosp 1, Dept Ultrasound, Harbin 150001, Peoples R China; [Lu, Shi-Yu] Chongqing Univ Sci & Technol, Coll Met & Mat Engn, Chongqing 401331, Peoples R China; [Wang, Jingjing] Peking Univ, Sch Mat Sci & Engn, Beijing Key Lab Magnetoelect Mat & Devices BKL MM, Beijing 100871, Peoples R China; [Zhou, Benqing] Shantou Univ, Coll Engn, Dept Biomed Engn, Shantou 515063, Peoples R China"

通信作者："Liu, H (通讯作者)，Southwest Univ, Minist Educ, Sch Mat & Energy, Key Lab Luminescence Anal & Mol Sensing, Chongqing 400715, Peoples R China.; Cao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China.; Zhou, BQ (通讯作者)，Shantou Univ, Coll Engn, Dept Biomed Engn, Shantou 515063, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001162302400001

JCR分区：Q1

影响因子：8.3

年份：2023

卷号：15

期号：36

开始页：42317

结束页：42328

文献类型：Article

关键词：carbonate nanosheets; responsive degradation; Fenton-like reaction; apoptosis; ferroptosis; tumor theranostics

摘要："Elimination of tumor cells using carbonate nanomaterials with tumor microenvironment-responsive capacity has been explored as an effective strategy. However, their therapeutic outcomes are always compromised by the relatively low intratumoral accumulation and limited synthesis method. Herein, a novel kind of basic copper carbonate nanosheets was designed and prepared using a green synthesis method for photoacoustic imaging-guided tumor apoptosis and ferroptosis therapy. These nanosheets were synthesized with the assistance of dopamine and ammonium bicarbonate (NH4HCO3) and the loading of glucose oxidase (GOx). NH4HCO3 could not only provide an alkaline environment for the polymerization of dopamine but also supply carbonates for the growth of nanosheets. The formed nanosheets displayed good acid and near-infrared light responsiveness. After intercellular uptake, they could be degraded to release Cu2+ and GOx, generating hydroxyl radicals through a Cu+-mediated Fenton-like reaction, consuming glucose, up-regulating H2O2 levels, and down-regulating GSH levels. Tumor elimination could be achieved by hydroxyl radical-induced apoptosis and ferroptosis. More amusingly, this synthesis method can be extended to several kinds of mono-element and multi-element carbonate nanomaterials (e.g., Fe, Mn, and Co), showing great potential for further tumor theranostics."

基金机构："Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0120, CSTB2022NSCQ-MSX0557]; Senior Medical Talents Program of Chongqing for Young and Middle-aged, the Young Elite Scientists Sponsorship Program by CAST [2021QNRC001]; Natural Science Foundation of Guangdong Province [2021A1515010441]; Talent Introduction of Chongqing University of Science and Technology [ckrc2021050]; 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant [2020LKSFG05C]"

基金资助正文："This research was funded by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0120 and CSTB2022NSCQ-MSX0557), the Senior Medical Talents Program of Chongqing for Young and Middle-aged, the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), the Natural Science Foundation of Guangdong Province (2021A1515010441), the 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant (2020LKSFG05C), and the Talent Introduction of Chongqing University of Science and Technology (ckrc2021050)."