Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs

作者全名："Yang, Sha; Huan, Renzheng; Deng, Mei; Luo, Tao; Peng, Shuo; Xiong, Yunbiao; Han, Guoqiang; Liu, Jian; Zhang, Jiqin; Tan, Ying"

作者地址："[Yang, Sha; Liu, Jian] Guizhou Univ, Med Coll, Guiyang 550025, Guizhou, Peoples R China; [Deng, Mei; Luo, Tao; Peng, Shuo; Xiong, Yunbiao; Han, Guoqiang; Liu, Jian; Tan, Ying] Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China; [Zhang, Jiqin] Guizhou Prov Peoples Hosp, Dept Anesthesiol, Guiyang, Peoples R China; [Huan, Renzheng] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China"

通信作者："Liu, J (通讯作者)，Guizhou Univ, Med Coll, Guiyang 550025, Guizhou, Peoples R China.; Liu, J; Tan, Y (通讯作者)，Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China.; Zhang, JQ (通讯作者)，Guizhou Prov Peoples Hosp, Dept Anesthesiol, Guiyang, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001175403800001

JCR分区：Q1

影响因子：3.4

年份：2024

卷号：10

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：RAMPs; Prognosis; Immunotherapy; Pan -cancer; Immune; Tumor microenvironment

摘要："Whether receptor activity-modifying proteins (RAMPs) play a key role in human cancer prognosis and immunity remains unknown. We used data from the public databases, The Cancer Genome Atlas, Therapeutically Applicable Research to Generate Effective Treatments, and the GenotypeTissue Expression project. We utilized bioinformatics methods, R software, and a variety of online databases to analyze RAMPs. In general, RAMPs were significantly and differentially expressed in multiple tumors, and RAMP expression was closely associated with prognosis, immune checkpoints, RNA-editing genes, tumor mutational burden, microsatellite instability, ploidy, and stemness indices. In addition, the expression of RAMPs is strongly correlated with tumorinfiltrating lymphocytes in human cancers. Moreover, the RAMP co-expression network is largely involved in many immune-related biological processes. Quantitative reverse transcription polymerase chain reaction and Western blot proved that RAMP3 was highly expressed in glioma, and RAMP3 promoted tumor proliferation and migration. RAMPs exhibit potential as prognostic and immune-related biomarkers in human cancers. Moreover, RAMPs can be potentially developed as therapeutic targets or used to enhance the efficacy of immunotherapy."

基金机构："National Natural Science Foundation of China, China [81960454, 82260533, 82360482]; Guizhou Provincial Science and Technology Projects [[2020]1Z066]; Guizhou Provincial People's Hospital National Science Foundation [GPPH-NSFC-2019-18]"

基金资助正文："This work was supported by the National Natural Science Foundation of China, China (81960454, 82260533, and 82360482), the Guizhou Provincial Science and Technology Projects ([2020]1Z066), Guizhou Provincial People's Hospital National Science Foundation (GPPH-NSFC-2019-18, 2019-09)."