The effectiveness and safety of human urinary kallidinogenase in acute ischemic stroke patients undergoing endovascular therapy

作者全名："Wang, Mengmeng; Guo, Changwei; Yang, Jie; Li, Jing; Hu, Jinrong; Peng, Zhouzhou; Guo, Meng; Zhang, Lingyu; Li, Fengli; Yang, Qingwu; Zi, Wenjie; Wang, Pengfei"

作者地址："[Wang, Mengmeng; Li, Jing; Zhang, Lingyu; Wang, Pengfei] Shandong Univ, Weihai Municipal Hosp, Cheeloo Coll Med, Dept Neurol, Jinan, Shandong, Peoples R China; [Wang, Mengmeng; Li, Jing; Zhang, Lingyu] Weifang Med Univ, Clin Coll, Weifang, Peoples R China; [Guo, Changwei; Yang, Jie; Hu, Jinrong; Peng, Zhouzhou; Li, Fengli; Yang, Qingwu; Zi, Wenjie] Army Med Univ, Mil Med Univ 3, Xinqiao Hosp, Chongqing, Peoples R China; [Guo, Changwei; Yang, Jie; Hu, Jinrong; Peng, Zhouzhou; Li, Fengli; Yang, Qingwu; Zi, Wenjie] Army Med Univ, Mil Med Univ 3, Affiliated Hosp 2, Chongqing, Peoples R China; [Guo, Meng] Thirteenth Peoples Hosp Chongqing, Chongqing, Peoples R China; [Guo, Meng] Second Affiliated Hosp Chongqing Med Univ, Dept Neurol, Chongqing, Peoples R China; [Wang, Pengfei] Shandong Univ, Weihai Municipal Hosp, Cheeloo Coll Med, Dept Neurol, 70 Heping Rd, Jinan 264200, Shandong, Peoples R China; [Zi, Wenjie] Army Med Univ, Mil Med Univ 3, Xinqiao Hosp, Dept Neurol, Chongqing 400037, Peoples R China; [Zi, Wenjie] Army Med Univ, Mil Med Univ 3, Affiliated Hosp 2, Chongqing 400037, Peoples R China"

通信作者："Wang, PF (通讯作者)，Shandong Univ, Weihai Municipal Hosp, Cheeloo Coll Med, Dept Neurol, 70 Heping Rd, Jinan 264200, Shandong, Peoples R China.; Zi, WJ (通讯作者)，Army Med Univ, Mil Med Univ 3, Xinqiao Hosp, Dept Neurol, Chongqing 400037, Peoples R China.; Zi, WJ (通讯作者)，Army Med Univ, Mil Med Univ 3, Affiliated Hosp 2, Chongqing 400037, Peoples R China."

来源：JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001181106800001

JCR分区：Q1

影响因子：4.9

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Human urinary kallidinogenase; endovascular therapy; large vessel occlusion; stroke

摘要："The effectiveness and safety of human urinary kallidinogenase (HUK) in acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) due to large vessel occlusion (LVO) was unclear. A pooled analysis was performed using individual data from the DEVT and RESCUE BT trials. Patients were divided into two groups based on HUK treatment. The primary outcome was the 90-day modified Rankin Scale (mRS) score. Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH) within 48 hours. A total of 1174 patients were included in the study. Of these, 150 (12.8%) patients received HUK. The adjusted common odds ratio (OR) of the mRS score was 1.458 (95% confidence interval [CI] = 1.072-1.983; p = 0.016) favoring HUK. The incidence of sICH (2.0% vs. 8.6%; adjusted OR: 0.198; 95% CI: 0.061-0.638; p = 0.007) and mortality (11.3% vs.18.5%; adjusted OR: 0.496; 95% CI: 0.286-0.862; p = 0.013) was lower in HUK group than non-HUK group. This association was consistent with propensity score-matching and the inverse probability of treatment weighting analysis. In conclusion, HUK was safe and associated with a preferable prognosis in AIS patients due to LVO in the anterior circulation."

基金机构：Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0926]; Weihai Municipal Hospital Subject Climbing Plan General Project [FH-2021-XY01]

基金资助正文："The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Chongqing Natural Science Foundation (cstc2020jcyj-msxmX0926) and Weihai Municipal Hospital Subject Climbing Plan General Project(FH-2021-XY01)."