Article Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension

作者全名："Zhang, Yunxia; Zhang, Meng; Yang, Hongwei; Li, Haobo; Ma, Shuangshuang; Xi, Linfeng; Li, Yishan; Li, Xincheng; Fu, Zhihui; Zhang, Zhu; Zhang, Shuai; Gao, Qian; Huang, Qiang; Wan, Jun; Xie, Wanmu; Li, Jifeng; Yang, Peiran; Zhai, Zhenguo"

作者地址："[Zhang, Yunxia; Yang, Hongwei; Li, Haobo; Ma, Shuangshuang; Xi, Linfeng; Li, Yishan; Li, Xincheng; Fu, Zhihui; Zhang, Zhu; Zhang, Shuai; Gao, Qian; Huang, Qiang; Xie, Wanmu; Yang, Peiran; Zhai, Zhenguo] Natl Ctr Resp Med, Beijing, Peoples R China; [Zhang, Yunxia; Yang, Hongwei; Li, Haobo; Ma, Shuangshuang; Xi, Linfeng; Li, Yishan; Li, Xincheng; Fu, Zhihui; Zhang, Zhu; Zhang, Shuai; Gao, Qian; Huang, Qiang; Xie, Wanmu; Yang, Peiran; Zhai, Zhenguo] State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China; [Zhang, Yunxia; Yang, Hongwei; Li, Haobo; Ma, Shuangshuang; Xi, Linfeng; Li, Yishan; Li, Xincheng; Fu, Zhihui; Zhang, Zhu; Zhang, Shuai; Gao, Qian; Huang, Qiang; Xie, Wanmu; Yang, Peiran; Zhai, Zhenguo] Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China; [Zhang, Yunxia; Yang, Hongwei; Li, Haobo; Ma, Shuangshuang; Xi, Linfeng; Li, Yishan; Li, Xincheng; Fu, Zhihui; Zhang, Zhu; Zhang, Shuai; Gao, Qian; Huang, Qiang; Xie, Wanmu; Yang, Peiran; Zhai, Zhenguo] Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China; [Zhang, Yunxia; Yang, Hongwei; Li, Haobo; Ma, Shuangshuang; Xi, Linfeng; Li, Yishan; Li, Xincheng; Fu, Zhihui; Zhang, Zhu; Zhang, Shuai; Gao, Qian; Huang, Qiang; Xie, Wanmu; Yang, Peiran; Zhai, Zhenguo] China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China; [Zhang, Meng] Capital Med Univ, Beijing Anzhen Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China; [Yang, Hongwei] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Li, Haobo; Fu, Zhihui] Chinese Acad Med Sci & Peking Union Med Coll, China Japan Friendship Hosp, Beijing, Peoples R China; [Ma, Shuangshuang] Beijing Univ Chinese Med, Beijing, Peoples R China; [Xi, Linfeng] Capital Med Univ, China Japan Friendship Hosp, Beijing, Peoples R China; [Li, Yishan] Shanxi Med Univ, Clin Med Coll 1, Taiyuan, Peoples R China; [Li, Xincheng] Harbin Med Univ, Harbin, Peoples R China; [Li, Jifeng] Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China; [Li, Jifeng] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Key Lab Resp & Pulm Circulat Disorders, Beijing, Peoples R China; [Li, Jifeng] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing, Peoples R China; [Li, Jifeng] Capital Med Univ, Dept Resp Dis, Beijing, Peoples R China; [Yang, Peiran] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China; [Yang, Peiran] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China"

通信作者："Zhai, ZG (通讯作者)，Natl Ctr Resp Med, Beijing, Peoples R China.; Zhai, ZG (通讯作者)，State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China.; Zhai, ZG (通讯作者)，Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China.; Zhai, ZG (通讯作者)，Chinese Acad Med Sci, Inst Resp Med, Beijing, Peoples R China.; Zhai, ZG (通讯作者)，China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China."

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001181136000001

JCR分区：Q1

影响因子：4.6

年份：2024

卷号：27

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Determining novel biomarkers for early identification of chronic thromboembolic pulmonary hypertension (CTEPH) could improve patient outcomes. We used the isobaric tag for relative and absolute quantitation approach to compare the serum protein profiles between CTEPH patients and the controls. Bioinformatics analyses and ELISA were also performed. We identified three proteins including heparanase (HPSE), gelsolin (GSN), and secreted protein acidic and rich in cysteine (SPARC) had significant changes in CTEPH. The receiver operating characteristic curve analysis showed that the areas under the curve of HPSE in CTEPH diagnosis were 0.988. Furthermore, HPSE was correlated with multiple parameters of right ventricular function. HPSE concentrations were significantly higher in patients with a low TAPSE/sPAP ratio (%0.31 mm/mmHg) (65.4 [60.5,68.0] vs. 59.9 [35.9,63.2] ng/mL, p < 0.05). The CTEPH patients treated by balloon pulmonary angioplasty had significantly lower HPSE levels. The study demonstrates that HPSE may be a promising biomarker for noninvasive detection of CTEPH."

基金机构："Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2021-I2M-1-061, 2021-I2M-1- 049]; National High Level Hospital Clinical Research Funding, Elite Medical Professionals Project of China -Japan Friendship Hospital [ZRJY2023-QM31]; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences Foundation for Young Scholars [2023-ZF-22]; National High Level Hospital Clinical Research Funding [2022-NHLHCRF-LX-01-0203]"

基金资助正文："This study was supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-061, 2021-I2M-1- 049) , National High Level Hospital Clinical Research Funding, Elite Medical Professionals Project of China -Japan Friendship Hospital (ZRJY2023-QM31) , Institute of Respiratory Medicine, Chinese Academy of Medical Sciences Foundation for Young Scholars (2023-ZF-22) , and National High Level Hospital Clinical Research Funding (2022-NHLHCRF-LX-01-0203) ."