Correlation of TBX21 gene polymorphisms with ankylosing spondylitis in a Chinese population

作者全名："Li, Lin; Shan, Jiankang; Fang, Haixin; An, Guangqi; Zhang, Min; Zhou, Pengyi; Xie, Kunpeng; Jin, Bo; Zhu, Haiyan; Jin, Xuemin; Yang, Peizeng; Du, Liping"

作者地址："[Li, Lin; Fang, Haixin; An, Guangqi; Zhou, Pengyi; Xie, Kunpeng; Jin, Bo; Zhu, Haiyan; Jin, Xuemin; Yang, Peizeng; Du, Liping] Zhengzhou Univ, Henan Prov Eye Hosp, Affiliated Hosp 1, Henan Int Joint Res Lab Ocular Immunol & Retinal I, Zhengzhou, Peoples R China; [Shan, Jiankang; An, Guangqi; Zhang, Min] Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Yang, PZ; Du, LP (通讯作者)，Zhengzhou Univ, Henan Prov Eye Hosp, Affiliated Hosp 1, Henan Int Joint Res Lab Ocular Immunol & Retinal I, Zhengzhou, Peoples R China."

来源：INTERNATIONAL JOURNAL OF IMMUNOGENETICS

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001182159100001

JCR分区：Q3

影响因子：2.3

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：ankylosing spondylitis; polymorphism; rs11657479; rs4794067; T-Bet; TBX21

摘要："Genome-wide association studies analysis has revealed associations between ankylosing spondylitis (AS) and loci on the TBX21 gene across various populations. This study aimed to investigate if there is a connection between a higher risk of AS in a Chinese population and two polymorphism loci on the TBX21 gene. To achieve this, we performed a case-control investigation involving 363 patients with AS and 907 healthy individuals. Genotyping was carried out using the iPLEX Gold genotyping assay. The analysis of genotypes and haplotypes was performed using SPSS 23.0 and SHEsis software. The results revealed no statistically significant correlation between the two specified single-nucleotide polymorphisms of TBX21 (rs11657479 C/T and rs4794067 C/T) and susceptibility to AS. However, upon conducting stratification analysis, our findings demonstrated a significant association between rs11657479 and susceptibility to human leucocyte antigen (HLA)-B27+ AS in allelic (C vs. T: odds ratio [OR] = 1.52, 95%CI = 1.09-2.11, corrected p [pc] = .028), heterozygous (CT vs. TT: OR = 1.63, 95%CI = 1.13-2.34, pc = .016) and dominant (CT + CC vs. TT: OR = 1.60, 95%CI = 1.12-2.28, pc = .018) models. Furthermore, the haplotype rs4794067/C-rs11657479/C of TBX21 was found to increase the risk of HLA-B27+ AS cases. In conclusion, our findings indicate a correlation between TBX21 gene polymorphism and HLA-B27+ AS patients within the Chinese population."

基金机构："National Natural Science Foundation of China; Medical Science and Technology Project of Health Commission of Henan Province [YXKC2020026]; Key Scientific Research Projects of Henan Province Colleges and Universities [23A320067]; Major Program of Medical Scientific and Technological of Henan Province (XXX); Medical Scientific and Technological Project of Henan Province [SBGJ2020003031]; [81970792]; [82171040,82301271]; [82101108]"

基金资助正文："This work was supported by National Natural Science Foundation of China [81970792, 82171040,82301271, 82101108], Medical Science and Technology Project of Health Commission of Henan Province [YXKC2020026], Key Scientific Research Projects of Henan Province Colleges and Universities [23A320067], Major Program of Medical Scientific and Technological of Henan Province (XXX), Medical Scientific and Technological Project of Henan Province (SBGJ2020003031)."