Comparative analysis of the nucleus accumbens transcriptional features in multiple depressive animal models

作者全名："Yu, Ying; Li, Xuemei; Teng, Teng; He, Yuqian; Jiang, Yuanliang; Liu, Xueer; Zhou, Xinyu; Luo, Yong; Xie, Peng"

作者地址："[Yu, Ying; Teng, Teng; He, Yuqian; Luo, Yong; Xie, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Yu, Ying; Li, Xuemei; Teng, Teng; He, Yuqian; Jiang, Yuanliang; Liu, Xueer; Zhou, Xinyu; Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Xuemei; Jiang, Yuanliang; Liu, Xueer; Zhou, Xinyu] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Luo, Y; Xie, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhou, XY (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：BEHAVIOURAL BRAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001182680500001

JCR分区：Q2

影响因子：2.6

年份：2024

卷号：463

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Depression; Nucleus accumbens; Stressor; Transcriptome

摘要："Chronic stress is deemed a significant clinical contributor to depression. The use of animal models of chronic stress can fully reveal the complex pathological mechanisms and their changing trends in the pathogenesis of depression, which is crucial for both disease prevention and therapy. It is also unknown how various forms of stress differ in their impact on animal physiology and behavior. The nucleus accumbens (NAc), an essential brain area for the pathophysiology of depression, and its underlying neural mechanisms remain unclear. Here, we systematically compared transcriptional signatures in the NAc of four chronic stress models in rats: chronic unpredictable mild stress (CUMS), chronic social defeat stress (CSDS), learned helplessness (LH), chronic restraint stress (CRS). The majority of differentially expressed genes (DEGs) were unique to a single depression model, while the rank-rank hypergeometric overlap analysis showed that the CSDS and CRS models had the greatest overlap, and the CRS and CUMS models had the least. Then, we performed pathway analysis of the differential genes and found that the neuroactive ligand-receptor interaction pathway was significantly enriched not only in the LH, CRS and CSDS stress models, but also significantly enriched in stress genes that were also altered in at least two stress models. Finally, we found three hub genes (Dcx, Tnc and Wdfy4) by constructing coexpression networks for stress genes. In summary, our research has the potential to offer fresh insights into the molecular mechanisms underlying depression induced by different types of stress, highlighting both their similarities and differences. It may provide valuable clues for understanding the pathogenesis of depression."

基金机构：National Key Research and Development Program of China [2017YFA0505700]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320002]; Natural Science Foundation Project of China [81820108015]; Major Program of Brain Science and Brain -Like Intelligence Technology [2022ZD0212900]; Chongqing Science and Technology Commission [cstc2020jcyj-jqX0024]

基金资助正文："This work was financially supported by the National Key Research and Development Program of China (Grant No. 2017YFA0505700 to P. X.) , the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (Grant No. 2019PT320002 to P.X.) , the Natural Science Foundation Project of China (Grant No. 81820108015 to P.X.) , the Major Program of Brain Science and Brain -Like Intelligence Technology (2022ZD0212900 to XZ) , the institutional funds from the Chongqing Science and Technology Commission (Grant No. cstc2020jcyj-jqX0024 to XZ) ."