Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke

作者全名："Dong, Yuhan; Long, Bo; Tian, Zhanglin; Huang, Junmeng; Wei, Youdong"

作者地址："[Dong, Yuhan; Long, Bo; Tian, Zhanglin; Huang, Junmeng; Wei, Youdong] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Wei, Youdong] Chongqing Key Lab Neurobiol, Chongqing, Peoples R China"

通信作者："Wei, YD (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：CLINICAL BIOCHEMISTRY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001186914100001

JCR分区：Q2

影响因子：2.5

年份：2024

卷号：125

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Ischemic stroke; SGLT2; Biomarker; Prognosis

摘要："Background: Recently acquired data suggests that sodium -glucose cotransporter-2 (SGLT2) may be a therapeutic target for cerebral ischemia. The specific impact of SGLT2 in acute ischemic stroke (AIS) remains unknown. We aimed to explore the levels of SGLT2 in AIS patients and its association with functional prognosis. Methods: In this study, 132 AIS patients and 44 healthy controls were recruited prospectively to determine serum SGLT2 levels. Logistic regression analysis was employed to assess the association between serum SGLT2 level and stroke risk as well as 3-month outcome. Receiver operating characteristic (ROC) curves were utilized to evaluate predictive values for blood biomarkers. Results: Serum SGLT2 levels were significantly higher (P =.000) in AIS patients (47.1 (interquartile range [IQR]: 42.4-50.9) ng/mL) than healthy controls (35.7 (IQR: 28.6-39.5) ng/mL). The optimal SGLT2 cutoff point for diagnosing AIS was 39.55 ng/mL, with a sensitivity of 90.2 % and specificity of 77.3 %. Serum levels of SGLT2 were negatively correlated with the onset time of AIS (linear fit R2 = 0.056, P =.006), but were not associated with National Institutes of Health Stroke Scale (NIHSS) scores (r = 0.007, P >.05) and lesion volume (r = -0.151, P >.05). SGLT2 was not remarkably different between patients with unfavorable and favorable outcomes (46.7 (IQR: 41.9-49.6) ng/mL vs 47.6 (IQR: 42.5-51.9) ng/mL; P =.321). Conclusions: The serum SGLT2 concentration may be a potential biomarker for the diagnosis of AIS. However, it does not exhibit any association with disease severity or functional prognosis."

基金机构："Chongqing Health and Family Planning Commission [2017MSXM023, 2017ZBXM046]"

基金资助正文：This study was supported by Chongqing Health and Family Planning Commission under grant numbers 2017MSXM023 and 2017ZBXM046.