Physical exercise frequency and cognition: a multicenter cross-sectional cohort study

作者全名："Wen, Chen; Gan, Jing-Huan; Huang, Guo-Wei; Wang, Xiao-Dan; Lue, Yang; Niu, Jian-Ping; Meng, Xin-Ling; Cai, Pan; Li, Yang; Gang, Bao-Zhi; You, Yong; Lv, Yan; Ren, Zhi-Hong; Liu, Shuai; Zeng, Yan; Ji, Yong"

作者地址："[Wen, Chen; Ji, Yong] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, Beijing, Peoples R China; [Gan, Jing-Huan] Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China; [Huang, Guo-Wei] Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Sci, Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin, Peoples R China; [Wang, Xiao-Dan; Liu, Shuai; Ji, Yong] Tianjin Huanhu Hosp, Tianjin Dementia Inst, Dept Neurol, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China; [Lue, Yang] Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Chongqing, Peoples R China; [Niu, Jian-Ping] Xiamen Med Coll, Dept Neurol, Affiliated Hosp 2, Xiamen, Peoples R China; [Meng, Xin-Ling] Xinjiang Med Univ, Dept Neurol, Affiliated Tradit Chinese Med Hosp, Urumqi, Peoples R China; [Cai, Pan] Zunyi Med Univ, Dementia Clin, Affiliated Hosp, Zunyi, Peoples R China; [Li, Yang] Shanxi Med Univ, Dept Neurol, Hosp 1, Taiyuan, Peoples R China; [Gang, Bao-Zhi] Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin, Peoples R China; [You, Yong] Hainan Med Univ, Dept Neurol, Affiliated Hosp 2, Haikou, Peoples R China; [Lv, Yan] Hainan Gen Hosp, Dept Neurol, Haikou, Peoples R China; [Ren, Zhi-Hong] Capital Med Univ, Beijing Elect Power Hosp, Dept Neurol, State Grid Corp China, Beijing, Peoples R China; [Zeng, Yan] Wuhan Univ Sci & Technol, Brain Sci & Adv Technol Inst, Wuhan, Peoples R China"

通信作者："Ji, Y (通讯作者)，Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, Beijing, Peoples R China.; Ji, Y (通讯作者)，Tianjin Huanhu Hosp, Tianjin Dementia Inst, Dept Neurol, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China.; Zeng, Y (通讯作者)，Wuhan Univ Sci & Technol, Brain Sci & Adv Technol Inst, Wuhan, Peoples R China."

来源：FRONTIERS IN AGING NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001189723700001

JCR分区：Q2

影响因子：4.1

年份：2024

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：physical exercise frequency; dementia; cognitive impairment; Alzheimer's disease; healthy guidance

摘要："Background and aims: Dementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency of physical exercise (physical exercise), we investigated the association between frequency of PE and cognition in Chinese old adults. Methods: 16,181 Chinese participants aged 65 years or older were included in this study. Associations between PE and cognition were estimated multivariate logistic and linear regression analyses. Associations were further investigated across dementia subtypes (Alzheimer dementia, vascular dementia, and other types of dementia). Subgroup analyses were performed in different age groups, in populations with and without stroke, and those with and without hypertension. Results: PE associated with dementia after adjusting for full covariates (OR: 0.5414, 95% CI: 0.4536-0.6491, p < 0.001). Exercise performed at >= 3 times/week associated with lower risk of dementia (OR: 0.4794-0.6619, all p value <0.001). PE was associated with improved cognition (beta: 12851, p < 0.001), and any PE frequency contributed to cognitive improvement (p values for exercise performed >= 1 time/week were <0.001). Similar conclusions were identified when we repeated analyses in different dementia subtypes and age groups. Subgroup analyses suggested that the cognition of individuals without hypertension also benefitted from exercising 1-2 times/week (OR: 0.6168, 95% CI: 0.4379-0.8668, p = 0.005). Conclusion: The best exercise frequency is exercising >= 3 times/week for individuals from different dementia subtypes and age groups. While for those without hypertension, PE at 1-2 times /week is also beneficial."

基金机构："Tianjin Science and Technology Plan Project [22ZYCGSY00840]; Tianjin Municipal Education Commission Research projects [2023KJ060]; Tianjin Health Research Project [TJWJ2023QN060, TJWJ2022MS032]; National Natural Science Foundation of China [82171182]; Tianjin Key Medical Discipline (Specialty) Construction Project [TJYXZDXK-052B]"

基金资助正文："The authors are grateful to all those who participated in this study and wish to acknowledge the valuable assistance obtained from all specialized physicians. We sincerely gratitude Jing Li (Tianjin Huanhu Hospital, Tianjin, China), Wen-Zheng Hu (Beijing Tiantan Hospital, Capital Medical University, Beijing, China), Xi-Yu Li (Tianjin Huanhu Hospital, Tianjin, China), Han Zhu (Wenzhou medical university, Tianjin, China), Xiao-Shan Du (Tianjin medical university, Tianjin, China), Wen-Jing Zhou (Tianjin medical university, Tianjin, China), and Ling-Yun Ma (Beijing Fuxing Hospital, Capital Medical University, Beijing, China) for the data collection and input. We would like to thank Yongjie Chen (Department of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China) for his great help in data analysis during the revision of the manuscript. We also thank the Tianjin Key Medical Discipline (Specialty) Construction Project for their help.r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The present study was supported by the Tianjin Science and Technology Plan Project [grant number 22ZYCGSY00840], Tianjin Municipal Education Commission Research projects [grant number 2023KJ060], Tianjin Health Research Project [grant numbers TJWJ2023QN060 and TJWJ2022MS032], National Natural Science Foundation of China [grant number 82171182] and Tianjin Key Medical Discipline (Specialty) Construction Project [grant number TJYXZDXK-052B]. The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication."