Cubic Zinc-Doped Iron Oxide Nanoparticles with Poly(Ethylene Glycol) or Sodium Citrate Surface Coatings for Tumor Imaging

作者全名："Sun, Xin; Tan, Mingya; Fang, Jingqin; Wang, Shunan; Guo, Yu; Cao, Zhile; Xie, Tian; Xu, Kai; Zhao, Zhenghuan; Zhang, Weiguo"

作者地址："[Sun, Xin; Fang, Jingqin; Wang, Shunan; Guo, Yu; Cao, Zhile; Xie, Tian; Zhang, Weiguo] Army Med Univ, Daping Hosp, Army Med Ctr PLA, Dept Radiol, Chongqing 400042, Peoples R China; [Tan, Mingya; Zhao, Zhenghuan] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Xu, Kai] Strateg Support Force Med Ctr, Dept Radiol, Beijing 100101, Peoples R China; [Zhang, Weiguo] Chongqing Clin Res Ctr Imaging & Nucl Med, Chongqing 400042, Peoples R China"

通信作者："Zhang, WG (通讯作者)，Army Med Univ, Daping Hosp, Army Med Ctr PLA, Dept Radiol, Chongqing 400042, Peoples R China.; Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.; Zhang, WG (通讯作者)，Chongqing Clin Res Ctr Imaging & Nucl Med, Chongqing 400042, Peoples R China."

来源：ACS APPLIED NANO MATERIALS

ESI学科分类：　

WOS号：WOS:001191206100001

JCR分区：Q2

影响因子：5.3

年份：2024

卷号：7

期号：7

开始页：7543

结束页：7554

文献类型：Article

关键词：differentiated surface coatings; high performance T (2) contrast agent; tumor imaging; morphology control; structure-activity relationship

摘要："Magnetic resonance imaging (MRI) has been extensively studied over the past few decades, so developing strategies to enhance the T-2 contrast is of significant importance. Herein, we synthesized a series of cubic zinc-doped iron oxide nanoparticles (CZINs) with different dopant ratios by the thermal decomposition method. CZINs with a dopant ratio of 1:5 show the best magnetic performance and T-2 relaxivity among all CZINs. More importantly, we demonstrate that differentiated surface modifications lead to diverse in vivo behavior of CZINs, resulting in the distinct contrast efficiency for different types of tumor. Compared to sodium citrate (SC)-modified CZINs, polyethylene glycol (PEG)-modified CZINs show lower protein absorption, longer blood circulation time, and lower uptake amount in liver. These behavior differences lead PEG-modified CZINs to be potential candidates for assisting precise subcutaneous tumor diagnosis, while SC-modified CZINs are more suitable for achieving accurate liver metastases imaging. This research holds significant promise to develop potential T-2 contrast agents, which can be translated into clinical practice."

基金机构：National Natural Science Foundation of China [81871421]; National Natural Science Foundation of China [CSTC2015YFPT-gcjsyjzx0175]; Fund of Chongqing Clinical Research Centre of Imaging and Nuclear Medicine

基金资助正文：This work was supported by the National Natural Science Foundation of China (81871421) and the Fund of Chongqing Clinical Research Centre of Imaging and Nuclear Medicine (CSTC2015YFPT-gcjsyjzx0175). Part of the Table of contents (TOC) graphic was created partially utilizing the templates on BioRender.com as a reference.