Bubble-like lucency in pulmonary ground glass nodules on computed tomography: a specific pattern of air-containing space for diagnosing neoplastic lesions

作者全名："Liu, Si-zhu; Yang, Shi-hai; Ye, Min; Fu, Bin-jie; Lv, Fa-jin; Chu, Zhi-gang"

作者地址："[Liu, Si-zhu; Yang, Shi-hai; Ye, Min; Fu, Bin-jie; Lv, Fa-jin; Chu, Zhi-gang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Yang, Shi-hai] Peoples Hosp Nanchuan Dist, Dept Radiol, 16 South St, Chongqing 408400, Peoples R China; [Ye, Min] First Peoples Hosp Neijiang, Dept Radiol, 31 Tuozhong Rd, Neijiang 641099, Sichuang, Peoples R China"

通信作者："Chu, ZG (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：CANCER IMAGING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001197240100001

JCR分区：Q1

影响因子：3.5

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Lung neoplasms; Differential; Diagnosis; Vacuoles; Tomography; X-Ray computed

摘要："Purpose To investigate the computed tomography (CT) characteristics of air-containing space and its specific patterns in neoplastic and non-neoplastic ground glass nodules (GGNs) for clarifying their significance in differential diagnosis. Materials and methods From January 2015 to October 2022, 1328 patients with 1,350 neoplastic GGNs and 462 patients with 465 non-neoplastic GGNs were retrospectively enrolled. Their clinical and CT data were analyzed and compared with emphasis on revealing the differences of air-containing space and its specific patterns (air bronchogram and bubble-like lucency [BLL]) between neoplastic and non-neoplastic GGNs and their significance in differentiating them. Results Compared with patients with non-neoplastic GGNs, female was more common (P < 0.001) and lesions were larger (P < 0.001) in those with neoplastic ones. Air bronchogram (30.1% vs. 17.2%), and BLL (13.0% vs. 2.6%) were all more frequent in neoplastic GGNs than in non-neoplastic ones (each P < 0.001), and the BLL had the highest specificity (93.6%) in differentiation. Among neoplastic GGNs, the BLL was more frequently detected in the larger (14.9 +/- 6.0 mm vs. 11.4 +/- 4.9 mm, P < 0.001) and part-solid (15.3% vs. 10.7%, P = 0.011) ones, and its incidence significantly increased along with the invasiveness (9.5-18.0%, P = 0.001), whereas no significant correlation was observed between the occurrence of BLL and lesion size, attenuation, or invasiveness. Conclusion The air containing space and its specific patterns are of great value in differentiating GGNs, while BLL is a more specific and independent sign of neoplasms."

基金机构：Joint Project of Chongqing Science and Technology Commission and Chongqing Public Health Commission [2022MSXM050]; Senior Medical Talents Program of Chongqing for Young and Middle-aged from Chongqing Health Commission

基金资助正文："This study has received funding by the Joint Project of Chongqing Science and Technology Commission and Chongqing Public Health Commission (2022MSXM050), and the Senior Medical Talents Program of Chongqing for Young and Middle-aged from Chongqing Health Commission (Receptor: Zhigang Chu)."