Au-Fe3O4 Janus nanoparticles for imaging-guided near infrared-enhanced ferroptosis therapy in triple negative breast cancer

作者全名：Wei, Ruixue; Fu, Gaoliang; Li, Zhe; Liu, Yang; Qi, Lingxiao; Liu, Kun; Zhao, Zhenghuan; Xue, Mengzhou

作者地址：[Wei, Ruixue; Li, Zhe; Liu, Yang; Qi, Lingxiao; Xue, Mengzhou] Zhengzhou Univ, Dept Cerebrovascular Dis, Affiliated Hosp 2, Zhengzhou 450001, Henan, Peoples R China; [Fu, Gaoliang] Huanghe Sci & Technol Coll, Inst Nanostruct Funct Mat, Henan Prov Key Lab Nanocomposites & Applicat, Zhengzhou 450006, Henan, Peoples R China; [Liu, Kun] Xinxiang Med Univ, Coll Med Engn, Xinxiang 453003, Henan, Peoples R China; [Zhao, Zhenghuan] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China

通信作者：Wei, RX (通讯作者)，Zhengzhou Univ, Dept Cerebrovascular Dis, Affiliated Hosp 2, Zhengzhou 450001, Henan, Peoples R China.; Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.

来源：JOURNAL OF COLLOID AND INTERFACE SCIENCE

ESI学科分类：CHEMISTRY

WOS号：WOS:001202498200001

JCR分区：Q1

影响因子：9.4

年份：2024

卷号：663

期号：　

开始页：644

结束页：655

文献类型：Article

关键词：Ferroptosis; Gold nanoparticle; Iron oxide nanoparticle; Photothermal; Reactive oxygen species

摘要：Triple -negative breast cancer (TNBC) is insensitive to conventional therapy due to its highly invasive nature resulting in poor therapeutic outcomes. Recent studies have shown multiple genes associated with ferroptosis in TNBC, suggesting an opportunity for ferroptosis-based treatment of TNBC. However, the efficiency of present ferroptosis agents for cancer is greatly restricted due to lack of specificity and low intracellular levels of H2O2 in cancer cells. Herein, we report a nano-theranostic platform consisting of gold (Au) -iron oxide (Fe3O4) Janus nanoparticles (GION@RGD) that effectively enhances the tumor -specific Fenton reaction through utilization of near -infrared (NIR) lasers, resulting in the generation of substantial quantities of toxic hydroxyl radicals (center dot OH). Specifically, Au nanoparticles (NPs) converted NIR light energy into thermal energy, inducing generation of abundant intracellular H2O2, thereby enhancing the iron -induced Fenton reaction. The generated center dot OH not only lead to apoptosis of malignant tumor cells but also induce the accumulation of lipid peroxides, causing ferroptosis of tumor cells. After functionalizing with the activity -targeting ligand RGD (Arg-Gly-Asp), precise synergistic treatment of TNBC was achieved in vivo under the guidance of Fe3O4 enhanced T2 -weighted magnetic resonance imaging (MRI). This synergistic treatment strategy of NIR-enhanced ferroptosis holds promise for the treatment of TNBC.

基金机构：National Natural Science Foundation of China [82071331, 81870942, 81520108011]; Natural Science Foundation of Henan Province of China [222300420328]; China Postdoctoral Science Foundation [2020TQ0289, 2021M692925]; Key R & D and Promotion Special Projects of Henan Province [232102231027]; Henan Medical Science and Technology Research Program Joint Construction Project [LHGJ20230326]; Key Scientific Research Projects of Higher Education Institutions in Henan Province [23A150050]

基金资助正文：This work was supported by the National Natural Science Foundation of China (82071331, 81870942 and 81520108011) , Natural Science Foundation of Henan Province of China (222300420328) , China Postdoctoral Science Foundation (2020TQ0289 and 2021M692925) , key R & D and Promotion Special Projects of Henan Province (NO. 232102231027) , Henan Medical Science and Technology Research Program Joint Construction Project (LHGJ20230326) , and the Key Scientific Research Projects of Higher Education Institutions in Henan Province (23A150050) .