Associations of serum gamma-linolenic acid levels with erythema severity and anxiety/depression status in patients with rosacea

作者全名："Tang, Jin-Yi; Chen, Mei-Ling; Wan, Mei; Wei, Jin-Yu; Qian, Tian; Fan, Yu-Kun; Yang, Zhi; Fu, Jian; Li, Jian"

作者地址："[Tang, Jin-Yi] Third Mil Med Univ, Southwest Hosp, Off Sci Res Adm, Div Med Affairs, Chongqing, Peoples R China; [Chen, Mei-Ling] Third Mil Med Univ, Southwest Hosp, Nucl Med Dept, Chongqing, Peoples R China; [Wan, Mei; Li, Jian] Third Mil Med Univ, Southwest Hosp, Dermatol Dept, Chongqing, Peoples R China; [Wei, Jin-Yu] 920th Hosp Joint Logist Support Force PLA, Dermatol Dept, Kunming, Peoples R China; [Qian, Tian; Fan, Yu-Kun; Yang, Zhi] Chongqing Med Univ, Affiliated Hosp 3, Dermatol Dept, Chongqing, Peoples R China; [Fu, Jian] Third Mil Med Univ, Southwest Hosp, Urol, Chongqing, Peoples R China"

通信作者："Li, J (通讯作者)，Third Mil Med Univ, Southwest Hosp, Dermatol Dept, Chongqing, Peoples R China.; Fu, J (通讯作者)，Third Mil Med Univ, Southwest Hosp, Urol, Chongqing, Peoples R China."

来源：ANAIS BRASILEIROS DE DERMATOLOGIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001205803300001

JCR分区：Q3

影响因子：1.7

年份：2024

卷号：99

期号：2

开始页：189

结束页：195

文献类型：Article

关键词：Gamma-linolenic acid; Mental disorders; Rosacea; Severity of illness index

摘要："Background: The development of rosacea is suggested to be closely associated with lipid metabolism, inflammation, and anxiety/depression. Gamma linolenic acid (GLA) is a key factor participating in lipid metabolism, which is also confirmed to regulate the inflammatory response. However, the associations of serum GLA levels with rosacea severity and psychological status still remain unclear. Objective and limitations of the study: The present study aimed to investigate the associations of gamma linolenic acid (GLA), a key factor participating in lipid metabolism and the inflammatory response, with rosacea severity and psychological status. The present study still had some limitations. First, this study is a cross-sectional study and does not provide longitudinal evidence about the relationship between GLA and rosacea; Second, the cohort in this study is also relatively small, and a larger cohort is needed in further investigation to reveal the potential role of lipid metabolism in the pathogenesis of rosacea. Methods: A total of 62 rosacea patients were consecutively recruited. Patient's Self-Assessment (PSA) scale and Clinician Erythema Assessment (CEA) as well as 7-item Generalized Anxiety Disorder (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9) were conducted to evaluate the degree of erythema severity and anxiety/depression, respectively. Serum GLA levels were determined by gas chromatography mass. Results: Lower levels of serum GLA in rosacea patients were observed (p < 0.001), and subgroup analysis revealed that patients with higher-level GLA had lower scores of PSA, CEA, GAD-7 and PHQ-9. Moreover, Spearman correlation analysis uncovered that serum GLA levels were negatively associated with PSA, CEA, GAD-7 as well and PHQ-9 scores, respectively. Linear regression model found that serum GLA levels at baseline were a predictive factor for prognosis of clinical outcomes after 1-month conventional treatment. Conclusion: The present study indicates that lower levels of serum GLA in rosacea patients are negatively associated with the degree of erythema and anxiety/depression status. (c) 2023 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)."

基金机构：Chongqing Sci-ence and Health Joint Medical Research Project [2023MSXM015]

基金资助正文：<BOLD>Financial support</BOLD> This study was supported by grants from the Chongqing Sci-ence and Health Joint Medical Research Project (Reference number: 2023MSXM015) .