Peripheral nerve injury associated with JEV infection in high endemic regions, 2016-2020: a multicenter retrospective study in China

作者全名：Wang, Guowei; Zhong, Lianmei; Wang, Manxia; Zhou, Juan; Liu, Shuting; Miao, Wang; Li, Leilei; Liu, Yonghong; Guo, Shougang; Li, Haining; Wang, Xiaoming; Xie, Liuqing; Xie, Min; Fu, Shihong; Xuan, Tingting; Li, Fan; Yang, Tingting; Shao, Lufei; Shi, Mingfang; Li, Xiaocong; Li, Xiaoling; Gao, Li; Zhai, Shaopeng; Ding, Jia; Wang, Tianhong; Liu, Dayong; Ma, Guosheng; Wu, Jiang; Wan, Dongjun; Guo, Junlin; Zhang, Xinbo; Wu, Jinxia; Wang, Yinxu; Jin, Ansong; Ma, Lei; Yang, Huan; He, Xuexian; Ma, Xiaona; Liu, Huijuan; Ma, Boya; Yang, Ningai; Hou, Xiaolin; Xu, Ting; Qin, Cheng-feng; Wang, Huanyu; Xie, Peng; Wang, Zhenhai

作者地址：[Wang, Guowei; Xuan, Tingting; Li, Xiaocong] Ningxia Med Univ, Clin Med Sch 1, Yinchuan, Peoples R China; [Zhong, Lianmei] Capital Med Univ, Xuanwu Hosp, Beijing, Peoples R China; [Wang, Manxia; Li, Xiaoling; Zhai, Shaopeng] Lanzhou Univ Second Hosp, Dept Neurol, Hosp 2, Lanzhou, Peoples R China; [Zhou, Juan] Guangzhou Women & Childrens Med Ctr, Guangzhou, Peoples R China; [Liu, Shuting] Ningxia Med Univ, Yinchuan, Peoples R China; [Miao, Wang] Zhengzhou Univ, Neurointens Care Unit, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Li, Leilei] Sichuan Univ, West China Hosp, Chengdu, Peoples R China; [Liu, Yonghong; Zhang, Xinbo] Air Force Med Univ, Xijing Hosp, Dept Neurol, Xian 710032, Peoples R China; [Guo, Shougang] Shandong First Med Univ, Shandong Prov Hosp, Jinan, Peoples R China; [Li, Haining; Shao, Lufei; Ma, Boya; Hou, Xiaolin; Wang, Zhenhai] Ningxia Med Univ, Neurol Ctr, Gen Hosp, Yinchuan, Peoples R China; [Wang, Xiaoming; Wang, Yinxu] North Sichuan Med Coll, Affiliated Hosp, Nanchong, Peoples R China; [Xie, Liuqing] Meishan Peoples Hosp, Meishan 620010, Peoples R China; [Xie, Min] Chengdu Seventh Peoples Hosp, Chengdu, Peoples R China; [Fu, Shihong; Li, Fan; Wang, Huanyu] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China; [Yang, Tingting; Ma, Xiaona; Yang, Ningai; Wang, Zhenhai] Ningxia Med Univ, Inst Med Sci, Gen Hosp, Yinchuan, Peoples R China; [Yang, Tingting; Ma, Xiaona; Yang, Ningai; Wang, Zhenhai] Diag & Treatment Engn Technol Res Ctr Nervous Syst, Yinchuan, Peoples R China; [Shi, Mingfang; Wu, Jinxia] Chongqing Med Univ, Dept Pediat, Childrens Hosp, Chongqing 400014, Peoples R China; [Gao, Li] Baoji Cent Hosp, Baoji, Peoples R China; [Ding, Jia] First Peoples Hosp Tianshui, Tianshui 741000, Peoples R China; [Wang, Tianhong] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China; [Liu, Dayong] Gansu Med Coll, Affiliated Hosp, Pingliang, Peoples R China; [Ma, Guosheng] Gansu Prov Peoples Hosp, Lanzhou, Peoples R China; [Wu, Jiang] First Peoples Hosp Longnan City, Longnan, Peoples R China; [Wan, Dongjun] Chinese Peoples Liberat Army, Hosp Joint Logist Support Force 940, Lanzhou, Peoples R China; [Guo, Junlin] Qingyang Peoples Hosp, Qingyang, Peoples R China; [Jin, Ansong] Kunming Med Univ, Affiliated Hosp 1, Kunming, Peoples R China; [Ma, Lei; Yang, Huan] Ningxia Med Univ, Emergency Ctr, Gen Hosp, Yinchuan, Peoples R China; [He, Xuexian] Gen Hosp Ningxia Med Univ, Yinchuan 750004, Ningxia, Peoples R China; [Liu, Huijuan] Ningxia Med Univ, Cerebrospinal Fluid Lab, Gen Hosp, Yinchuan, Peoples R China; [Xu, Ting] Ningxia Med Univ, Dept Infect Dis, Gen Hosp, Yinchuan, Peoples R China; [Qin, Cheng-feng] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China; [Xie, Peng] Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China; [Xie, Peng] Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Wang, ZH (通讯作者)，Ningxia Med Univ, Neurol Ctr, Gen Hosp, Yinchuan, Peoples R China.; Wang, HY (通讯作者)，Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China.; Wang, ZH (通讯作者)，Ningxia Med Univ, Inst Med Sci, Gen Hosp, Yinchuan, Peoples R China.; Wang, ZH (通讯作者)，Diag & Treatment Engn Technol Res Ctr Nervous Syst, Yinchuan, Peoples R China.; Qin, CF (通讯作者)，Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, NHC Key Lab Diag & Treatment Brain Funct Dis, Chongqing, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Chongqing, Peoples R China.

来源：EMERGING MICROBES & INFECTIONS

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001206087100001

JCR分区：Q1

影响因子：8.4

年份：2024

卷号：13

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Japanese encephalitis virus; peripheral nerve injury; clinical classification; endemic; electromyography

摘要：Previously, we reported a cohort of Japanese encephalitis (JE) patients with Guillain-Barr & eacute; syndrome. However, the evidence linking Japanese encephalitis virus (JEV) infection and peripheral nerve injury (PNI) remains limited, especially the epidemiology, clinical presentation, diagnosis, treatment, and outcome significantly differ from traditional JE. We performed a retrospective and multicenter study of 1626 patients with JE recorded in the surveillance system of the Chinese Center for Disease Control and Prevention, spanning the years 2016-2020. Cases were classified into type 1 and type 2 JE based on whether the JE was combined with PNI or not. A comparative analysis was conducted on demographic characteristics, clinical manifestations, imaging findings, electromyography data, laboratory results, and treatment outcomes. Among 1626 laboratory confirmed JE patients, 230 (14%) were type 2 mainly located along the Yellow River in northwest China. In addition to fever, headache, and disturbance of consciousness, type 2 patients experienced acute flaccid paralysis of the limbs, as well as severe respiratory muscle paralysis. These patients presented a greater mean length of stay in hospital (children, 22 years [range, 1-34]; adults, 25 years [range, 0-183]) and intensive care unit (children, 16 years [range, 1-30]; adults, 17 years [range, 0-102]). The mortality rate was higher in type 2 patients (36/230 [16%]) compared to type 1 (67/1396 [5%]). The clinical classification of the diagnosis of JE may play a crucial role in developing a rational treatment strategy, thereby mitigating the severity of the disease and potentially reducing disability and mortality rates among patients.

基金机构：Science and Technology Key Research Program of Ningxia

基金资助正文：We thank the study participants for their contributions to data collection and the following persons for their critical contributions to this project: Xinyi Li (Shanxi Bethune Hospital), Li Gu (The First People's Hospital of Yibin), Jianjun Zhang (Baoji Central Hospital), Xiaomin Li (North Sichuan Medical College), Xiaojun Yang, Xiangchun Ding, Tao Guo, Zhijun Zhao, Qiang Liu, Na Shao (all group members in General Hospital of Ningxia Medical University), Liping Yang, Kaichun Shen, Yanping Yuan and Na Zhang (all group members in Ningxia Medical University).