Association between diabetes mellitus and primary restenosis following endovascular treatment: a comprehensive meta-analysis of randomized controlled trials

作者全名：Sun, Xiaolei; Zhang, Cheng; Ma, Yarong; He, Yanzheng; Zhang, Xiaodong; Wu, Jianbo

作者地址：[Sun, Xiaolei; He, Yanzheng] Southwest Med Univ, Affiliated Hosp, Dept Gen Surg Vasc Surg, Luzhou 646000, Peoples R China; [Sun, Xiaolei] Southwest Med Univ, Affiliated Hosp, Dept Intervent Med, Luzhou 646000, Peoples R China; [Wu, Jianbo] Southwest Med Univ, Basic Med Res Innovat Ctr Cardiometab Dis, Sch Pharm, Minist Educ,Dept Pharmacol, Luzhou 646000, Peoples R China; [Wu, Jianbo] Southwest Med Univ, Sch Pharm, Lab Cardiovasc Pharmacol, Luzhou 646000, Peoples R China; [Sun, Xiaolei] Southwest Med Univ, Lab Nucl Acids Med Natl High Level Talents, Nucl Acid Med Luzhou Key Lab, Luzhou 646000, Peoples R China; [Sun, Xiaolei; Wu, Jianbo] Southwest Med Univ, Inst Cardiovasc Res, Key Lab Med Electrophysiol, Minist Educ, Luzhou 646000, Peoples R China; [Sun, Xiaolei; Wu, Jianbo] Southwest Med Univ, Inst Cardiovasc Res, Collaborat Innovat Ctr Prevent & Treatment Cardiov, Med Electrophysiol Key Lab Sichuan Prov, Luzhou 646000, Peoples R China; [Sun, Xiaolei; Wu, Jianbo] Cardiovasc & Metab Dis Key Lab Luzhou, Luzhou 646000, Peoples R China; [Ma, Yarong] Southwest Med Univ, Affiliated Hosp, Dept Ophthalmol, Luzhou 646000, Peoples R China; [Zhang, Xiaodong] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Clin Res Ctr Reprod Med, Ctr Reprod Med, Chongqing, Peoples R China; [Sun, Xiaolei] Kings Coll London, British Heart Fdn Ctr Res Excellence, Fac Life Sci & Med, Sch Cardiovasc Med & Sci, London SE5 9NU, England; [Zhang, Cheng] Southwest Jiaotong Univ, Affiliated Hosp, Peoples Hosp Chengdu 3, Dept Gen Surg,Ctr Vasc & Intervent Surg, Chengdu 610031, Peoples R China; [Zhang, Cheng] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China

通信作者：Sun, XL (通讯作者)，Southwest Med Univ, Affiliated Hosp, Dept Gen Surg Vasc Surg, Luzhou 646000, Peoples R China.; Sun, XL (通讯作者)，Southwest Med Univ, Affiliated Hosp, Dept Intervent Med, Luzhou 646000, Peoples R China.; Wu, JB (通讯作者)，Southwest Med Univ, Basic Med Res Innovat Ctr Cardiometab Dis, Sch Pharm, Minist Educ,Dept Pharmacol, Luzhou 646000, Peoples R China.; Sun, XL (通讯作者)，Southwest Med Univ, Lab Nucl Acids Med Natl High Level Talents, Nucl Acid Med Luzhou Key Lab, Luzhou 646000, Peoples R China.; Sun, XL; Wu, JB (通讯作者)，Southwest Med Univ, Inst Cardiovasc Res, Key Lab Med Electrophysiol, Minist Educ, Luzhou 646000, Peoples R China.; Sun, XL; Wu, JB (通讯作者)，Southwest Med Univ, Inst Cardiovasc Res, Collaborat Innovat Ctr Prevent & Treatment Cardiov, Med Electrophysiol Key Lab Sichuan Prov, Luzhou 646000, Peoples R China.; Sun, XL; Wu, JB (通讯作者)，Cardiovasc & Metab Dis Key Lab Luzhou, Luzhou 646000, Peoples R China.; Zhang, XD (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Chongqing Clin Res Ctr Reprod Med, Ctr Reprod Med, Chongqing, Peoples R China.; Sun, XL (通讯作者)，Kings Coll London, British Heart Fdn Ctr Res Excellence, Fac Life Sci & Med, Sch Cardiovasc Med & Sci, London SE5 9NU, England.

来源：CARDIOVASCULAR DIABETOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001206348500001

JCR分区：Q1

影响因子：8.5

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：Importance Diabetes mellitus (DM) is thought to be closely related to arterial stenotic or occlusive disease caused by atherosclerosis. However, there is still no definitive clinical evidence to confirm that patients with diabetes have a higher risk of restenosis. Objective This meta-analysis was conducted to determine the effect of DM on restenosis among patients undergoing endovascular treatment, such as percutaneous transluminal angioplasty (PTA) or stenting. Data sources and study selection The PubMed/Medline, EMBASE and Cochrane Library electronic databases were searched from 01/1990 to 12/2022, without language restrictions. Trials were included if they satisfied the following eligibility criteria: (1) RCTs of patients with or without DM; (2) lesions confined to the coronary arteries or femoral popliteal artery; (3) endovascular treatment via PTA or stenting; and (4) an outcome of restenosis at the target lesion site. The exclusion criteria included the following: (1) greater than 20% of patients lost to follow-up and (2) a secondary restenosis operation. Data extraction and synthesis Two researchers independently screened the titles and abstracts for relevance, obtained full texts of potentially eligible studies, and assessed suitability based on inclusion and exclusion criteria.. Disagreements were resolved through consultation with a third researcher. Treatment effects were measured by relative ratios (RRs) with 95% confidence intervals (CIs) using random effects models. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Main outcomes and measures The main observation endpoint was restenosis, including > 50% stenosis at angiography, or TLR of the primary operation lesion during the follow-up period. Results A total of 31,066 patients from 20 RCTs were included. Patients with DM had a higher risk of primary restenosis after endovascular treatment (RR = 1.43, 95% CI: 1.25-1.62; p = 0.001). Conclusions and relevance This meta-analysis of all currently available RCTs showed that patients with DM are more prone to primary restenosis after endovascular treatment.

基金机构：International Science and Technology Innovation Cooperation Project of Sichuan Province [22GJHZ0278]; Sichuan Science and Technology Program [2022YFS0614, 2022YFS0617]; Medical Research Project of Sichuan Province [S21020]; Science and Technology Strategic Cooperation Project of Luzhou Municipal People's Government; Southwest Medical University [2021LZXNYD-D10, 23YKDCXY0003]; Doctoral Research Initiation Program of the Affiliated Hospital of Southwest Medical University [19041]

基金资助正文：This study was supported by the International Science and Technology Innovation Cooperation Project of Sichuan Province (22GJHZ0278), the Sichuan Science and Technology Program (2022YFS0614; 2022YFS0617), the Medical Research Project of Sichuan Province (S21020), the Science and Technology Strategic Cooperation Project of Luzhou Municipal People's Government and Southwest Medical University (2021LZXNYD-D10; 23YKDCXY0003), and the Doctoral Research Initiation Program of the Affiliated Hospital of Southwest Medical University (19041)