Prediction of early recovery of graft function after living donor liver transplantation in children

作者全名：Tan, Bingqian; Yang, Chenyu; Hu, Jiqiang; Xing, Huiwu; Zhang, Mingman

作者地址：[Tan, Bingqian; Yang, Chenyu; Hu, Jiqiang; Xing, Huiwu; Zhang, Mingman] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Hepatobiliary Surg,Childrens Hosp, Chongqing Key Lab Pediat,Minist Educ,Key Lab Child, Chongqing 400000, Peoples R China; [Xing, Huiwu] Zhengzhou Univ, Affiliated Hosp 1, Dept Pediat Surg, Zhengzhou 450000, Henan, Peoples R China

通信作者：Xing, HW; Zhang, MM (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Hepatobiliary Surg,Childrens Hosp, Chongqing Key Lab Pediat,Minist Educ,Key Lab Child, Chongqing 400000, Peoples R China.; Xing, HW (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Pediat Surg, Zhengzhou 450000, Henan, Peoples R China.

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001207900600023

JCR分区：Q1

影响因子：3.8

年份：2024

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Living donor liver transplantation; Children; Graft function recovery; Nomogram; Ambispective cohort study

摘要：For end-stage liver disease in children, living donor liver transplantation (LDLT) is often the important standard curative treatment. However, there is a lack of research on early recovery of graft function after pediatric LDLT. This is a single-center, ambispective cohort study. We collected the demographic and clinicopathological data of donors and recipients, and determined the risk factors of postoperative delayed recovery of hepatic function (DRHF) by univariate and multivariate Logistic analyses. 181 cases were included in the retrospective cohort and 50 cases in the prospective cohort. The incidence of DRHF after LDLT in children was 29.4%, and DRHF could well evaluate the early recovery of graft function after LDLT. Through Logistic analyses and AIC score, preoperative liver function of donors, ischemia duration level of the liver graft, Ln (Cr of recipients before operation) and Ln (TB of recipients on the 3rd day after operation) were predictive indicators for DRHF after LDLT in children. Using the above factors, we constructed a predictive model to evaluate the incidence of postoperative DRHF. Self-verification and prospective internal verification showed that this prediction model had good accuracy and clinical applicability. In conclusion, we pointed many risk factors for early delayed recovery of graft function after LDLT in children, and developed a visual and personalized predictive model for them, offering valuable insights for clinical management.

基金机构：Henan Sunshine Medical Health Development Foundation IGanDan Project

基金资助正文：We would like to acknowledge to the patients for sharing their clinical data selflessly.