Aperiodic components and aperiodic-adjusted alpha-band oscillations in children with ADHD

作者全名：Chen, Ran; Liu, Wen-juan; Wang, Jiu-Ju; Zhou, Dong -Dong; Wang, Yu-feng

作者地址：[Chen, Ran; Wang, Jiu-Ju; Zhou, Dong -Dong] Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing 401331, Peoples R China; [Liu, Wen-juan] Beijing Normal Univ, Fac Psychol, Beijing, Peoples R China; [Wang, Jiu-Ju; Wang, Yu-feng] Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China; [Wang, Jiu-Ju; Wang, Yu-feng] Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China; [Wang, Jiu-Ju; Wang, Yu-feng] Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing, Peoples R China; [Zhou, Dong -Dong] Peking Univ, Hosp 6, 51 Huayuanbei Rd, Beijing 100191, Peoples R China

通信作者：Wang, JJ; Zhou, DD (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing 401331, Peoples R China.; Zhou, DD (通讯作者)，Peking Univ, Hosp 6, 51 Huayuanbei Rd, Beijing 100191, Peoples R China.

来源：JOURNAL OF PSYCHIATRIC RESEARCH

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001214765800001

JCR分区：Q1

影响因子：3.7

年份：2024

卷号：173

期号：　

开始页：225

结束页：231

文献类型：Article

关键词：Attention-deficit/hyperactivity disorder; EEG; Neural oscillation; Aperiodic signal

摘要：This study aimed to investigate the aperiodic properties and aperiodic-adjusted alpha-band oscillations in children with ADHD, focusing on the influence of different scalp regions and lateralization on these neural correlates. Sixty-two ADHD children and 52 typical developing children aged 6-12 years were enrolled. EEG recordings were made with eyes closed for a minimum of 6 min. The 'FOOOF' was used to compute aperiodic parameters (exponent and offset), and aperiodic-adjusted alpha-band features including center frequency (CF), adjusted power (AP), and bandwidth (BW). Mixed-design ANOVAs were conducted with two between-subjects levels (ADHD and control groups) and two within-subjects' factors (lateralization and scalp region). ANCOVAs were conducted after accounting for sex and age. The ADHD group showed a significantly lower exponent compared to the control group, and this difference was not influenced significantly by factors like lateralization, scalp region, or sex. There were no notable distinctions between the groups for other measures. We noticed alpha-band CF tends to increase with age, while only frontal AP shows a significant positive correlation with age. Significant main effects of sex and lateralization were observed for offset, along with an interaction effect between sex and lateralization for CF. Our findings indicate that children aged 6-12 with ADHD have a markedly lower exponent, suggesting that this measure could potentially serve as a biomarker for ADHD. Future studies should consider factors such as age, sex, lateralization, and scalp region when investigating aperiodic and aperiodic-adjusted features.

基金机构：National Natural Science Foundation of China [31900752]

基金资助正文：This work was supported by the National Natural Science Foundation of China (31900752, to Jiuju Wang) .