A magnetic solid phase extraction based on DES/ZIF-MGO coupled with UPLC-MS/MS for the simultaneous detection and consumption evaluation of four illicit drugs

作者全名：Liu, Yujie; Cao, Shurui; Tian, Jie; You, Jiade; Liu, Zhenghong; Chen, Zhiqiong

作者地址：[Liu, Yujie; Chen, Zhiqiong] Chongqing Med Univ, Coll Pharm, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Cao, Shurui; Tian, Jie; You, Jiade; Liu, Zhenghong] Southwest Univ Polit Sci & Law, Forens Identificat Ctr, Chongqing 401120, Peoples R China; [Cao, Shurui] Southwest Univ Polit Sci & Law, Criminal Invest Law Sch, Chongqing 401120, Peoples R China

通信作者：Chen, ZQ (通讯作者)，Chongqing Med Univ, Coll Pharm, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.

来源：MICROCHEMICAL JOURNAL

ESI学科分类：CHEMISTRY

WOS号：WOS:001215480700001

JCR分区：Q1

影响因子：4.9

年份：2024

卷号：200

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Illicit drugs; MSPE-UPLC/MS-MS; Nanoparticles; Wastewater-based epidemiology

摘要：The social and environment effects of illicit drug abuse are a growing global concern. Wastewater-based epidemiology (WBE) has become a common monitoring tool for assessing drug consumption. In this study, mechanical carrier (MGO), skeletal framework (ZIF-67) and functional modification (DES) were together prepared a three-dimensional nanocomposite (DES/ZIF-MGO) as an adsorbent, and developed an ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method coupled with optimal MSPE for the determination of ultra-trace illicit drugs in wastewater. The method exhibited good linearity (R2 >= 0.9985) with low limit of detection (0.02-1.55 mu g/L) and qualified recovery (92.1-100.9 %) for four illicit drugs (AM, METH, MDMA and MC). The characterization results showed that electrostatic, hydrogen bond, and pi-pi interaction contributed to the adsorption process. The drug consumption in a city was investigated using WBE. MC was not detected in any of the wastewater samples. The detection rates of METH and MDMA were 100 % and 82 %, respectively, while AM was found in about 18 % of the wastewater samples. Thus, based on advantages of the DES/ZIF-MGO nanocomposite, the proposed method is a rapid, sensitive and reliable method for the determination of trace illicit drugs in wastewater.

基金机构：Chongqing Municipal Education Commission [KJZD-K202100301]; Chongqing Science and Technology Commission [cstc2021jcyj-msxmX0715]

基金资助正文：The work was supported by the Chongqing Municipal Education Commission (Grant No. KJZD-M202200301) ; the Chongqing Municipal Education Commission (Grant No. KJZD-M202300301) ; the Chongqing Municipal Education Commission (Grant No. KJZD-K202100301) ; the Chongqing Science and Technology Commission (Grant No. cstc2021jcyj-msxmX0715) ;