Windows of sensitivity for risk of adverse birth outcomes related to gestational PM2.5 exposure: Evidence from a natural experiment

作者全名：Ni, Wei; Xing, Yuhan; Li, Guoju; Du, Zhanhui; Yang, Ping; Wang, Qinzheng; Yang, Xinmeng; Lyu, Bei; Fa, Hongge; Shi, Qiuling; Xing, Quansheng

作者地址：[Ni, Wei; Li, Guoju; Du, Zhanhui; Yang, Ping; Wang, Qinzheng; Yang, Xinmeng; Lyu, Bei; Fa, Hongge; Xing, Quansheng] Qingdao Univ, Qingdao Women & Childrens Hosp, 6 Tongfu Rd, Qingdao 266000, Shandong, Peoples R China; [Xing, Yuhan] Chinese Univ Hong Kong, Fac Med, Dept Paediat, Hong Kong, Peoples R China; [Ni, Wei; Shi, Qiuling] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Xing, Yuhan] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen 518107, Guangdong, Peoples R China

通信作者：Xing, QS (通讯作者)，Qingdao Univ, Qingdao Women & Childrens Hosp, 6 Tongfu Rd, Qingdao 266000, Shandong, Peoples R China.

来源：ENVIRONMENTAL POLLUTION

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:001218861500001

JCR分区：Q1

影响因子：7.6

年份：2024

卷号：347

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Gestational PM 2.5 exposure; Adverse birth outcome; Congenital abnormality; Satellite -retrieval; Window of sensitivity

摘要：While numerous studies have associated maternal exposure to PM 2.5 with adverse birth outcomes, findings remain inconsistent and difficult to generalize. We aimed to investigate the causal relationship and window of sensitivity between gestational exposure to PM 2.5 and birth outcomes. We leveraged high -resolution satellite data to quantify gestational PM 2.5 exposure at the individual level, along with a combined model to determine daily relative risks (RRs) of birth outcomes in COVID-19 prelockdown and lockdown groups. RRs between the two groups were further compared using a longitudinal pre -post non -experimental design to identify sensitivity windows of adverse birth outcomes. A total of 73,781 pregnant women from the COVID-19 prelockdown group and 6267 pregnant women from the lockdown group were included for analysis. The daily mean PM 2.5 concentrations in the lockdown group decreased by 21.7% compared to the prelockdown group. During the first trimester, every 10 mu g/m 3 increase in PM 2.5 significantly increased the risk of congenital abnormalities of major organs such as the cardiovascular system, gastrointestinal tract, nervous system, urinary system, and respiratory system. Moreover, gestational exposure to PM 2.5 during the first trimester was associated with higher risks of premature delivery and term low birth weight. While PM 2.5 exposure during the second trimester was positively correlated with macrosomia. Gestational exposure to PM 2.5 is associated with increased risks of various adverse birth outcomes with specific sensitive windows. We demonstrated that gestational exposure to PM 2.5 increased risks of various adverse birth outcomes with specific window of sensitivity through the natural experiment design. Our findings underscore the urgent need for policies and initiatives targeting PM 2.5 reduction, especially during critical periods of pregnancy.

基金机构：National Natural Science Foundation of China (NSFC) [82071583, 82300031]; Distinguished Taishan Scholars (2019)

基金资助正文：This work is supported by The National Natural Science Foundation of China (NSFC) [Grant No: 82071583, 82300031] and Distinguished Taishan Scholars (2019) . We thank Qingdao Municipal Bureau of Ecology and Environment for coordinating data collection for PM<SUB>2.5</SUB> in Qingdao.