Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder

作者全名：Xu, Ke; Zhao, Shuang; Ren, Yi; Zhong, Qi; Feng, Jinzhou; Tu, Dianji; Wu, Wentao; Wang, Jiaolin; Chen, Jianjun; Xie, Peng

作者地址：[Xu, Ke; Ren, Yi; Feng, Jinzhou; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Xu, Ke; Ren, Yi; Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Chongqing, Peoples R China; [Zhao, Shuang] Chongqing Med Univ, Inst Viral Hepatitis, Dept Infect Dis, Key Lab Mol Biol Infect Dis,Minist Educ,Affiliated, Chongqing, Peoples R China; [Zhao, Shuang] Chongqing Med Univ, Dept Histol & Embryol, Lab Stem Cell & Tissue Engn, Chongqing, Peoples R China; [Zhong, Qi; Wu, Wentao; Wang, Jiaolin; Chen, Jianjun] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Tu, Dianji] Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Clin Lab, Chongqing, Peoples R China

通信作者：Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China.; Xie, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Natl Hlth Commiss Key Lab Diag & Treatment Brain F, Chongqing, Peoples R China.; Chen, JJ (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China.

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:001219685900001

JCR分区：Q1

影响因子：5.8

年份：2024

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：The pathogenesis of major depressive disorder (MDD) involves lipid metabolism. Our earlier research also revealed that MDD patients had much lower total cholesterol (TC) concentrations than healthy controls (HCs). However, it is still unclear why TC decreased in MDD. Here, based on the Ingenuity Knowledge Base's ingenuity pathway analysis, we found that sodium voltage-gated channel alpha subunit 11A (SCN11A) might serve as a link between low lipid levels and MDD. We analyzed the TC levels and used ELISA kits to measure the levels of SCN11A in the serum from 139 MDD patients, and 65 HCs to confirm this theory and explore the potential involvement of SCN11A in MDD. The findings revealed that TC levels were considerably lower and SCN11A levels were remarkably increased in MDD patients than those in HCs, while they were significantly reversed in drug-treatment MDD patients than in drug-na & iuml;ve MDD patients. There was no significant difference in SCN11A levels among MDD patients who used single or multiple antidepressants, and selective serotonin reuptake inhibitors or other antidepressants. Pearson correlation analysis showed that the levels of TC and SCN11A were linked with the Hamilton Depression Rating Scales score. A substantial association was also found between TC and SCN11A. Moreover, a discriminative model made up of SCN11A was discovered, which produced an area under a curve of 0.9571 in the training set and 0.9357 in the testing set. Taken together, our findings indicated that SCN11A may serve as a link between low lipid levels and MDD, and showed promise as a candidate biomarker for MDD.

基金机构：National Key R&D Program of China (2017YFA0505700),Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320002),National Natural Science Foundation of China (81820108015) [2017YFA0505700]; National Key R&D Program of China [2019PT320002]; Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences [81820108015, 82301720]; National Natural Science Foundation of China [2023MD734128]; China Postdoctoral Science Foundation [2023CQBSHTB2010]; Chongqing Postdoctoral Special Support Foundation [CSTB2023NSCQ-BHX0214]; Chongqing Postdoctoral Science Foundation [CYYY-BSHPYXM-202310]; First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation

基金资助正文：We sincerely thank the Department of Psychiatry, First Hospital of Chongqing Medical University for their help with human blood collection. This work was supported by the National Key R&D Program of China (2017YFA0505700), the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2019PT320002), the National Natural Science Foundation of China (81820108015, 82301720), the China Postdoctoral Science Foundation (2023MD734128), the Chongqing Postdoctoral Special Support Foundation (2023CQBSHTB2010), the Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214), and the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310).