Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy

作者全名："Peng, Qiao; Lv, Siting; Wen, Yidi; Wang, Lianlian; Gui, Wenwu"

作者地址："[Peng, Qiao] Suining Cent Hosp, Reprod Med Ctr, Suining 629000, Sichuan, Peoples R China; [Peng, Qiao] Suining Cent Hosp, Prenatal Diag Ctr, Suining 629000, Sichuan, Peoples R China; [Lv, Siting] Peoples Hosp Yubei Dist Chongqing City, Dept Obstet & Gynecol, Chongqing 401120, Peoples R China; [Wen, Yidi] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Ultrasonog, Chongqing 400014, Peoples R China; [Wang, Lianlian; Gui, Wenwu] Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, 1 Youyi Rd, Chongqing 400042, Peoples R China"

通信作者："Gui, WW (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, 1 Youyi Rd, Chongqing 400042, Peoples R China."

来源：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001234531500002

JCR分区：Q2

影响因子：3.1

年份：2024

卷号：41

期号：8

开始页：2137

结束页：2144

文献类型：Article

关键词：Early pregnancy; Kisspeptin/KISS-1; Menstruation cycle; Ovulation induction; Polycystic ovarian syndrome

摘要："PurposeTo examine the pattern of kisspeptin expression throughout the menstrual cycle in polycystic ovary syndrome (PCOS) patients under the ovulation induction and identify any possible associations with early pregnancy.Materials and methodsA prospective cohort of 80 PCOS women who expressed the desire for fertility was enrolled in this study. All of them received the ovulation induction by using letrozole. Levels of kisspeptin, luteinizing hormone (LH), and estradiol (E2) were measured at three different time points during menstruation. The early pregnancy rate was recorded for the study participants after three ovulation cycles.ResultsKisspeptin levels varied regularly during the menstrual cycle, reaching a peak on the day of hCG injection and decreasing after ovulation. There was no significant correlation between kisspeptin and LH levels. Basal kisspeptin levels decreased after letrozole treatment without a significant difference while LH and E2 levels decreased significantly. PCOS participants who became pregnant early had higher basal kisspeptin levels compared to non-pregnant PCOS patients, which had a significant difference (P = 0.006). And the average basal kisspeptin level in pregnant patients was 2293.0 +/- 398.7 pg/ml, with a 95% confidence interval of 1511.5-3074.5 pg/ml.ConclusionKisspeptin levels in PCOS women undergoing ovulation induction showed a regular variation, which was similar with the healthy women reported in previous studies. The use of LE may result in PCOS endocrine improvement and fertility achievement. In a certain range, kisspeptin might be a potential predictor for early pregnancy in PCOS patients as people with slightly higher basal kisspeptin levels seemed more likely to be pregnant."

基金机构：Science and Technology Planning Project of Yuzhong District of Chongqing City; First Affiliated Hospital of Chongqing Medical University

基金资助正文：We would like to thank The First Affiliated Hospital of Chongqing Medical University for providing the scientific research support for this manuscript.