The Impact of Sarcopenia on the Clinical Outcomes of Percutaneous Kyphoplasty in Patients With Osteoporotic Vertebral Compression Fracture: A Retrospective Cohort Study

作者全名：Wu, Shan; Zhong, Dian; Zhao, Guosheng; Liu, Yang; Ke, Zhenyong; Wang, Yang

作者地址：[Wu, Shan; Zhong, Dian; Zhao, Guosheng; Liu, Yang; Ke, Zhenyong; Wang, Yang] Chongqing Med Univ, Affiliated Hosp 2, Dept Spine Surg, 76 Linjiang Rd, Chongqing 400010, Peoples R China

通信作者：Wang, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Spine Surg, 76 Linjiang Rd, Chongqing 400010, Peoples R China.

来源：GERIATRIC ORTHOPAEDIC SURGERY & REHABILITATION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001241842800001

JCR分区：Q2

影响因子：1.6

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：percutaneous kyphoplasty; osteoporosis vertebral compression fracture; sarcopenia; appendicular skeletal muscle index; residual back pain; refracture

摘要：Objective: This study aimed to explore the impact of sarcopenia on clinical outcomes after percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fracture (OVCF). Methods: We retrospectively analyzed the medical records of patients with single-segment OVCF who underwent percutaneous kyphoplasty (PKP) between September 2021 and August 2022. Patients were categorized into a sarcopenia group (43 patients) and a non-sarcopenia group (125 patients) based on their Advanced Skeletal Muscle Index (ASMI). Clinical and radiological data were collected and analyzed. Results: There were no significant differences between the sarcopenia and non-sarcopenia groups in age, sex, bone mineral density (BMD), body mass index (BMI), fractured segment, fracture type, surgical approach, bone cement volume, bone cement distribution, comorbidities, preoperative and immediate postoperative VAS and ODI scores (P > .05). However, the time to ambulation, hospital stays, VAS and ODI scores at follow-up, excellent/good rate, and the incidence of residual pain and re-fractures in the non-sarcopenia group were significantly better than those in the sarcopenia group (P < .05). Meanwhile, radiological outcomes, including regional kyphosis and vertebral height loss rate, were significantly better in the non-sarcopenia group than in the sarcopenia group at 6 and 12 month follow-ups (P < .05). Conclusion: Clinical outcomes after PKP in patients with OVCF could be negatively affected by sarcopenia. Therefore, prevention and treatment of sarcopenia should be actively considered in the management of patients with OVCF.

基金机构：Program for Youth Innovation in Future Medicine, Chongqing Medical University

基金资助正文：We acknowledge to the multidisciplinary team in the Second Affiliated Hospital of Chongqing Medical University, including colleagues in orthopedics, radiology and anesthesiology, for their participation in the treatment planning and implementation and the preparation of this article.