Risk factors affecting long-term efficacy of ultrasound-guided high-intensity focused ultrasound treatment for multiple uterine fibroids

作者全名：Lin, Zhenjiang; Xu, Feng; Yuan, Yuan; Peng, Jiaojiao; Luo, Jin; Gong, Chunmei; Chen, Dayong; Wang, Yangyang; Wang, Donghong; Yang, Bing; Zhang, Lian

作者地址：[Lin, Zhenjiang; Xu, Feng; Yuan, Yuan; Gong, Chunmei; Chen, Dayong; Zhang, Lian] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Lin, Zhenjiang; Peng, Jiaojiao; Luo, Jin; Chen, Dayong; Wang, Donghong; Yang, Bing] Zunyi Med Univ, Affiliated Hosp, Dept Obstet & Gynaecol, Zunyi, Guizhou, Peoples R China; [Xu, Feng] Shijiazhuang Peoples Hosp, Dept Gynecol, Shijiazhuang, Hebei, Peoples R China; [Yuan, Yuan] Southwest Med Univ, Affiliated Hosp, Sichuan Prov Ctr Gynaecol & Breast Dis, Luzhou, Sichuan, Peoples R China; [Gong, Chunmei; Wang, Yangyang] Chongqing Haifu Hosp, Dept Radiol, Chongqing, Peoples R China

通信作者：Zhang, L (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China.

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001247573400001

JCR分区：Q2

影响因子：3

年份：2024

卷号：41

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：High-intensity focused ultrasound; multiple uterine fibroids; long-term results; recurrence; re-intervention

摘要：ObjectivesTo investigate the long-term efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for multiple uterine fibroids and the factors associated with recurrence.Materials and methodsFive hundred and forty-nine patients with multiple uterine fibroids treated with USgHIFU from June 2017 to June 2019 were retrospectively analyzed. The Pictorial Blood Loss Assessment Chart (PBAC) was used to assess menstrual blood loss. The patients were asked to undergo pre- and post-USgHIFU magnetic resonance imaging (MRI) and complete routine follow-up after USgHIFU. Cox regression analysis was used to investigate the risk factors associated with recurrence.ResultsThe median number of fibroids per patient was 3 (interquartile range: 3-4), and a total of 1371 fibroids were treated. Among them, 446 patients completed 3 years follow-up. Recurrence, defined as PBAC score above or equal to 100 and/or the residual fibroid volume increased by 10%, was detected in 90 patients within 3 years after USgHIFU, with a cumulative recurrence rate of 20.2% (90/446). The multi-factor Cox analysis showed that age was a protective factor for recurrence. Younger patients have a greater chance of recurrence than older patients. Mixed hyperintensity of fibroids on T2WI and treatment intensity were risk factors for recurrence. Patients with hyperintense uterine fibroids and treated with lower treatment intensity were more likely to experience recurrence than other patients after USgHIFU. No major adverse effects occurred.ConclusionsUSgHIFU can be used to treat multiple uterine fibroids safely and effectively. The age, T2WI signal intensity and treatment intensity are factors related to recurrence.

基金机构：Chongqing Natural Science Foundation Postdoctoral Fund [cstc2021jcyj-bshX0048]

基金资助正文：This study was supported by Chongqing Natural Science Foundation Postdoctoral Fund. Project No.: cstc2021jcyj-bshX0048.